Parameters

Control I

(practically healthy animals), n = 7

Chronic ischemic heart damage

Control II

0.9% NaCl, n = 7

Main I

+ traditional treatment, n = 10

Main, II

+ Adenocin^®, N = 11

Body weight, kg

3.24 ± 0.14

2.81 ± 0.14

2.90 ± 0.21

3.02 ± 0.18^#

Heart weight, g

4.38 ± 0.22

7.89 ± 0.28^**

6.28 ± 0.24^**#

4.56 ± 0.21^##++

Left ventricle weight, g

3.14 ± 0.12

4.64 ± 0.18^**

4.35 ± 0.10^*#

3.17 ± 0.11^##++

Cardiac hypertrophic index¹ Heart:body ratio × 10⁻³

1.96 ± 0.21

2.81 ± 0.18^**

2.51 ± 0.14^*#

2.17 ± 0.13^##+

LV:heart ratio

0.49 ± 0.04

0.59 ± 0.04^*

0.60 ± 0.08

0.48 ± 0.04^#

Heart dry weight, g

1.18 ± 0.04

1.23 ± 0.08

1.17 ± 0.07

1.14 ± 0.05^#

Cardiac wet-to-dry weight ratio

5.41 ± 0.16

6.41 ± 0.15^*

6.22 ± 0.14^*

5.75 ± 0.20^#

Relative lung weight, g/kg body

2.31 ± 0.12

2.31 ± 0.12

2.31 ± 0.12

2.31 ± 0.12

dP/dt max, mmHg/s

2456 ± 345

2456 ± 345

2456 ± 345

2456 ± 345

dP/dt min, mmHg/s

3100 ± 410

3100 ± 410

3100 ± 410

3100 ± 410

EDP, mmHg

5.4 ± 0.9

15.7 ± 1.9^***

14.4 ± 1.3^***

5.4 ± 0.8^###+++

BNP, pmol/ml

4.5 ± 2.1

18 ± 3^***

12.4 ± 2.4^***#

6.1 ± 2.4^###++