Observation

Pretreatment

Visit 2

Visit 3

Change during treatment period

Weight (kg)

72.8 (±11.91).

73.17 (±12.11)

73.11 (±12.00)

p = 0.342

BMI (kg/cm²)

25.97 ( ±3.062)

26.10 (±3.10)

26,03 (±3.102)

p = 0.008

Systolic blood pressure (mmHg)

133.4 (±10.85)

129.1 (±7.37)

128.3 (±7.24)

p < 0.0001

Diastolic blood pressure (mmHg)

86.53 (±8.84)

84.16 (±6.9)

83.87 (±6.81)

p < 0.0001

Heart rate (bpm)

69.60 (±4.52)

68.22 (±5.55)

67.91 (±5.12)

p = 0.0001

Respiratory rate (ipm)

15.77 (±2.07)

15.67 (±1.97)

16.04 (±4.32)

p = 0.23