Colvero, MO;

Colvero, AP;

Fiori, RM;

Garcia, PC. Novas opções terapêuticas na síndrome de

aspiração de mecônio. Rev. Bras. Saúde Matern. Infant.



Sistematic review

Review the literature on meconium aspiration syndrome (MAS), focusing on clinical, pathophysiological aspects and the therapeutic approach, with

emphasis on the use of surfactant and bronchoalveolar lavage.

- An ECMO is one of the main indications of the mas tomb, but it is extremely expensive, invasive and is not available in our country. It is recommended that newborns (NB) expose a mechanism that is aspirated by the wall suction system, and the tracheal intubator is indicated in cases where the NB suffering from respiratory depression, or the use of CPAP should be considered in diseases lighter, with careful monitoring of complications.

- It is controversial or use of antibiotic therapy, being commonly recommended in view of the severity of the condition and infectious process. The replacement and bronchoalveolar lavage with surfactant are being studied, showing themselves as effective measures in the prevention of breast cancer.

Hofmeyr GJ, Xu, H. Amnioinfusion for meconium-stained liquor in labour. Cochrane Database of Systematic Reviews

2010 [14]


Retrospective analysis

To evaluate the effects of amnioinfusion for meconium fluid on the perinatal outcome.

- In units with standard peripartum surveillance, the evidence does not support the benefits in practice regarding the use of amnioinfusion for meconium amniotic fluid, since it is an invasive procedure and its benefits have not been clearly identified in clinical studies. It is concluded that there is a need to conduct more research.

- In units with limited peripartum surveillance, 2 studies show significant improvements with the simplified amnioinfusion technique in pregnant women with oligodramnios. It is concluded that there is a need for further studies to determine the benefits of amnioinfusion in the sense of being limited only to women with oligodramnium pregnancies, and the possible risks for the mother.

Hofer N, Jank K, Resch E, Urlesberger B, Reiterer F, Resch B. Meconium Aspiration Syndrome—a 21-years’ Experience from a Tertiary Care Center and Analysis of Risk Factors for Predicting Disease Severity. Klin Padiatr.



Retrospective analysis

Describe the course of perinatal factors in neonates with

meconium aspiration syndrome (MAS) of

1990-2010 and determine risk factors for disease severity.

- The study was carried out at the tertiary care service affiliated with the university, researching newborns (NBs) diagnosed with MAS between 1990 and 2010, totaling a sample of 8000 NBs, 2600 of whom were born in that service.

- 205 NBs were diagnosed with MAS. Among the main risk factors for MAS are: neonatal asphyxia, post-term newborns, acute tocolysis, fetal distress and severe delivery.

- The study concludes that there was an apparent reduction in the incidence of MAS that can be explained by a better knowledge of risk factors and advances in obstetric practices.

Lin HC; Wu SY; Wu, JM; Yeh, T. Meconium aspiration syndrome: experiences in Taiwan. Journal of Perinatology

2008 [15]


Retrospective analysis

Review and summarize previous studies on meconium aspiration syndrome (MAS) in two tertiary neonatal centers in Taiwan.

- The incidence of MAS has decreased in Taiwan in the past decade, as the population has access to better health and care services.

- Increased mortality is associated with children with MAS who required resuscitation maneuvers, asphyxiation at birth and newborns who developed pulmonary hypertension and pneumothorax.

- The use of dexamethasone reduced the inflammatory process and improved cardiopulmonary perfusion, not preventing the development of pulmonary hypertension, but its use is still being studied.