| Included Article | Objective | Study Design | Data/Results | Conclusion |
| Thinkhamrop et al. 2013 [13] Cochrane Review | Effectiveness and safety of antibiotic prophylaxis compared to placebo or no treatment in women undergoing transcervical intrauterine procedures | Systematic search in different medical databases, a.o. Pubmed | No RCT’s available, so no trials were included | No conclusion can be drawn |
| Nappi et al. 2013 [1] | Double-blind, randomized, placebo-controlled study to assess incidence of infectious complications and the protective effect of antibiotic administration during operative hysteroscopic procedures in an office setting | Reference group treated with 1gram cefazoline i.m., study group treated with placebo 10 mL NaCl solution. Primary outcome: difference between two groups in postoperative infectious complications within 5 days postoperative | 1046 women included; 523 in study group, 523 in reference group. Postoperative infections: 12/1046 (=1.15%) women had infectious complications: 7 in reference group, 5 in study group (ns, p > 0.05) | It is recommended not to prescribe routine antibiotic administration in the case of hysteroscopic surgery |
| Bhattacharya et al. 1995 [14] | Effect of prophylactic antibiotics on the incidence of bacteraemia following hysteroscopy | Prospective randomised study. Patients: 106 women endometrial laser ablation or transcervical resection of endometrium intervention: 55 women 1200 mg Augmentin iv, 61 women no antibiotic treatment. Blood culture after procedure. | Infection in untreated group: 16% vs 2% in antibiotic prophylaxis group (significant difference). Study prematurely ended. Eventually no difference in clinically postoperative infectious manifestations | There is no convincing evidence that antibiotics are of value in this clinical setting |
| Morrill et al. 2013 [15] | To critically review gynaecology-specific data regarding surgical antibiotic prophylaxis in selected benign gynaecologic surgeries | Review including RCT’s on benign gynaecological surgeries other than hysterectomy in which antibiotic prophylaxis is compared to placebo or no antibiotic treatment | Only one article included on hysteroscopy: article by Bhattacharya et al. 1995 | There is no convincing evidence that antibiotics are of value in this clinical setting |