No.	Year	CNR	Range/Extended		syndromes			Pathogens	Number of cases	Commentary (publication reference)
1	2006	Malaria drug resistant	national		Diagnostic test			Plasmodium falciparum	6 tests assessed including 4 retained	BCP Malaria, CareStartTM Malaria pLDH, Acurate Malaria Test, SD Malaria Antigen: could be used in the diagnosis of malaria (Report 2006 (Unpublished data).
2	2006	Bacterial meningitis	Regional epidemic (Séguela, Bouna, Bouaké, tengrela, dabakala, daloa, soubre, boundiali)		Meningeal syndrome			N, meningitidis A N, meningitidis W135 N, non-typeable meningitidis S, pneumoniae	49 cases	These data enabled the Ministry of Health and Public Hygiene via the National Institute of Public Hygiene to carry out a vaccination response in the health districts affected by the epidemic (Report 2006; Unpublished data).
3	2006	Cholera and shigellosis	epidemic in 3 health districts (Abidjan and 2 in western Côte d’Ivoire (Danané and Zouan Hounien).		Gastroenteritis syndrome			Vibrio cholera	21 cases	The age group most affected by cholera is between 16 and 45 years old. Children were the least affected (Report 2006 [14] ).
4	2006	Agents of sexually transmitted infections	national		Diagnostic test			Human Immunodeficiency Virus (HIV)	3 tests assessed including 1 retained	Chek plus HIV 1 - 2 sensitivity and specificity 100%, report 2006 (Unpublished data).
5	2006	Measles	National epidemic: 37 health districts		Nasopharyngeal syndrome			measles virus	11 cases	(Report 2006; Unpublished data).
6	2006	Influenza and respiratory virus	LANADA (animal sample)		surveillance			Influenza viruses	22 cases	7 positive (including 5 H5N1) (Unpublished data).
7	2006	Influenza and respiratory virus	Sentinel site and national investigation		Human nasopharyngeal syndrome			Influenza viruses	46 cases	23 positive 3 positive (ELISA) 10 Flu M gene positives (Unpublished data).
8	2006	Yellow fever	Epidemic		hemorrhagic fever			yellow fever virus	376 cases	2 sera from Côte d’Ivoire which proved positive for IgM-type anti-yellow fever antibodies were confirmed by the regional laboratory, IP Dakar.
9	2006	Poliomyelitis	surveillance		AFP			wild poliovirus	1570 cases	0 wild poliovirus after cell culture, 181 non-polio enterovirus 14 vaccine-derived polio virus (Unpublished data).
10	2007	Bacterial meningitis	National epidemic		Meningeal syndrome	N.meningitidis A N.meningitidis C N.meningitidis W135 N.meningitidis sp. S.pneumoniae H. influenzae B Streptococcus agalactiae B			98 cases	Three techniques are used at CNR level. These are culture, the search for soluble antigens and PCR. The interest of PCR in the detection of bacteria in CSF is undeniable given the results (Report 2007; Unpublished data).
11	2007	Poliomyelitis	surveillance		AFP	Non-polio enterovirus vaccine-derived polio virus			1626	0 wild poliovirus after cell culture, 163 non-polio enterovirus 16 vaccine-derived polio virus Unpublished data).
12	2007	Influenza and respiratory viruses	surveillance		flu syndrome	RSV Parainfluenza virus			425 cases	Each sample was tested simultaneously by the ELISA technique for the identification of type and B influenza viruses and inoculated on MDCK cells for viral isolation. Secondarily, the search for the viral genome of influenza A, B and C, Metapneumovirus, RSV, Parainfluenza 1, 2, 3 and 4, rhinovirus, and Coronavirus OC 43 and 229E viruses was carried out by molecular biology. Of the 425 samples, 40 were positive for influenza, i.e. a prevalence of 9.41%. 13 cases or 3.06% of RSV infection were confirmed. The search for Parainfluenza viruses was carried out on 94 samples from the Pediatrics department of the University Hospital of Treichville and made it possible to highlight 9 cases of infection by Parainfluenza viruses. Unpublished data.
13	2007	Measles	surveillance		Nasopharyngeal syndrome	Anti-measles specific IgM			348 cases	Measles confirmation: For all suspected cases based on sera: 13.1% (Unpublished data).
14	2008	Tuberculosis	Slaughterhouse		Tuberculosis in cattle	Mr bovis			104 cases	the first time in Côte d’Ivoire, that Mycobacterium bovis was isolated from cattle slaughtered at the slaughterhouse, to confirm the existence of animal tuberculosis (Cissé et al. 2008; CISSE et al. 2008).
15	2009	Bacterial meningitis	Epidemic		Meningeal syndrome	S.pneumoniae H. influenzae b Neisseria meningitidis 3 N.meningitidis. VS N.meningitidis. B S. agalactiae Cryptococcus neoformans			29 cases	the emergence of NmW135 in Côte d’Ivoire, as well as the simultaneous disappearance of NmA (Soumahoro et al. 2018).
16	2009	Poliomyelitis	surveillance	Acute flaccid paralysis		wild-type poliovirus Non-polio enterovirus vaccine-derived polio virus			102 cases	After treatment, inoculation and intratypic differentiation, 102 cases of poliovirus were isolated, i.e. 15%, of which 53 were type 1 wild type poliovirus. 47 were of vaccine origin including 40 type 1, 6 type 2 and 1 type 3 (2007 Report; Unpublished data).
17	2009	Measles	National outbreak	Nasopharyngeal syndrome		Anti-measles specific IgM			762 cases	64 health districts were affected by positive cases of measles with recrudescence in the districts of Abidjan (2007 report; Unpublished data).
18	2009	Influenza and respiratory viruses	sentinel surveillance, pandemic influenza investigation	flu syndrome		influenza A and B viruses virus type A, type H3N2 virus type A, type H1N1 untypeable virus			1360 samples 456 positive cases	Influenza virus types A and B circulated. Type A viruses, 167 (50.45%) were of the H3N2 subtype and 37.46% were non-typeable. Two cases of influenza A (H1N1)2009 have been diagnosed in patients from the United States. Antigenic characterization of circulating strains was performed at the WHO collaborating center, Atlanta). All A (H3N2) viruses were antigenically close to the A/BRISBANE/10/2007-LIKE (H3N2) strain. The A (H1N1) virus strains were antigenically close to the A/California/07/2009 (H1N1)v strain (Report 2009; (Unpublished data).
19	2009	Rage	surveillance	animal bite		Lyssavirus			32 samples	2 confirmed human cases of rabies (Report 2009; Unpublished data).
20	2010	Measles	National outbreak	Nasopharyngeal syndrome		Anti-measles specific IgM			913 suspected cases	461 cases have been confirmed with an annual prevalence of 50.49%. The prevalence for the year 2009 was 24.27% with 185 confirmed cases out of 713 samples taken from suspected cases. This situation was linked to measles outbreaks in the districts of Abidjan West and Abidjan East (Report 2010; Unpublished data).
21	2010	Yellow fever	yellow fever and dengue fever epidemic	Hemorrhagic fever		Dengue virus Yellow Fever Virus			964 suspected cases	Epidemiological, biological and entomological investigations around confirmed cases of dengue fever and yellow fever in the Montagnes, Sud Comoé and Worodougou health regions, particularly in 04 health districts The entomological component consisted of capturing adult mosquitoes (135 batches of mosquitoes, Séguéla/Man/Zouan-Hounien/Aboisso), (Report 2010; Unpublished data).
22	2010	Influenza and respiratory viruses	sentinel surveillance, pandemic influenza investigation		flu syndrome		influenza A and B viruses type B virus, virus type A, type H3N2 virus type A(H1N1)v non-typeable viruses		447 cases	Absence of circulation of seasonal A (H1N1) viruses and almost permanent circulation of the pandemic virus and an upsurge of type B viruses.
23	2011	Cholera and Shigellosis	Investigation of an outbreak of cholera Attecoubé		gastroenteritis		Vibrio cholera		634 cases	ongoing monitoring for drug resistance can help choose a standardized treatment regimen. Further genotypic characterization of Vibrio choleraeO1 isolates will be needed [15] .
23	2011	Cholera and Shigellosis	Investigation of an outbreak of cholera Attecoubé		gastroenteritis		Vibrio cholera		634 cases
24	2011	Diarrhea virus	epidemiological and virological monitoring of pediatric rotavirus diarrhea in five (5) sentinel sites (CHU Yopougon, CHU Cocody, HGYOPAT, HGAN, HGPB).		diarrhea monitoring		rotavirus diarrhea; enterovirulent viruses		200 cases	(Report 2011; Unpublished data).
25	2012	Influenza and respiratory viruses	surveillance of cases of flu-like illnesses and surveillance of severe acute respiratory infections		flu syndromes and surveillance of severe acute respiratory infections		virus type A and B A(H1N1) pdm09 virus co-infections between types and subtypes of influenza viruses.		111	Cases of co-infections between types and subtypes of influenza viruses have been observed (Report 2012; Unpublished data).
26	2012	ORMICI	Monitoring Multi-Resistant Bacteria abidjan and CHR				ESBL-producing Enterobacteriaceae Staphylococcus Meti R		Hurt 24.6% SAMR 29.4	The monitoring of the evolution of BMR (Multi-Resistant Bacteria) shows a catastrophic situation in our hospitals but also in the city of Abidjan. These figures challenge us. It is time to react. Infections will become increasingly untreatable (Report 2012; Unpublished data).
27	2012	Cholera and shigellosis	Regional cholera epidemic (south comoé)		gastroenteritis		V. cholerae were serogroup O1.		67 cases	In different African epidemiological settings, substantial variation has occurred in cholera incidence, age distribution, clinical presentation, culture confirmation, and testing frequency. These results can help guide prevention activities, including the use of vaccines (Sauvageot et al. 2016).
28	2012	Bacterial meningitis	National epidemic		Meningeal syndrome	Neisseria meningitdis serogroup W135			163 cases	travelers to the meningitis belt of sub-Saharan Africa may be at risk of infection with N. meningitidis serogroup W135 (Taha et al. 2013).
29	2012	Tuberculosis	Animal pathology laboratory		Tuberculosis syndrome in cattle	Mr bovis			1 case	(Report 2012; Unpublished data).
30	2012	RIISIN	-Public structures 5 Services of the CHU of Cocody -SAMU -3 Private medical structures		monitoring the circulation of pathogenic bacteria in the hospital environment	Enterobacteriaceae No Enterobacteriaceae Staphylococcus spp Streptococcus species Pseudomonas multi-resistant			249 samples	Pseudomonas multi-resistant and resistant to Imipenem was observed for the first time in the intensive care unit of the University Hospital of Cocody. An alert was given to the Ministry of Health and the Fight against AIDS on February 7, 2012.
31	2013	Yellow fever	Epidemic		Hemorrhagic fever	yellow fever virus			7	(Report 2012; Unpublished data).
32	2013	Bacterial meningitis	Laboratory network monitoring		Meningeal syndrome	-S. pneumonia -NmA -NmC -NmW135 -Hib -S agalactiae			28 cases	The majority of the samples came from the health region of Abidjan 2. The main germs were S. pneumoniae followed by N. m W135. Northern regions included in the meningitis belt sent fewer samples. Several hypotheses can be mentioned: difficulties in transporting CSF to the CNRm, reduction in cases of meningitis following the vaccination campaign (tetravalent vaccine ACYW135).
33	2013	Influenza and respiratory virus	Surveillance		ARI in children	other non-influenza respiratory viruses			1509 ca	Multiplex RT-PCR assays targeting 10 severe acute respiratory infection (SARI) respiratory viruses were tested [16] .
34	2015	Rage	Diagnosis of rabies in suspected persons on biopsy of skin, saliva and urine		Rabies suspect	rabies virus			10 cases	All samples processed by molecular techniques were found to be positive. (Tiembre et al. 2010).
34	2015	Rage			Rabies suspect	rabies virus			10 cases
35	2015	Hemorrhagic fever	the threat of the Ebola virus fever epidemic,		Ebola suspect	Hemorrhagic fever virus			5 sera of suspected cases	negative results in Ebola gene amplification test but vigilance must remain.
36	2017	Hemorrhagic fevers	National epidemic		Hemorrhagic fever	Dengue virus			2849 samples	DENV-2 dominated this outbreak even though all three serotypes were detected by RT-PCR. The increasing trend of co-circulation of dengue virus serotypes suggests that Abidjan is transitioning from an endemic to a hyperendemic state [17] .
37	2018	Hemorrhagic fevers	dengue fever outbreak		Hemorrhagic syndrome	dengue virus, lassa virus			1 case	fatal human case of Lassa fever in Bangolo district in western Côte d’Ivoire in 2015 [18] .
38	2019	Hemorrhagic fevers	District Abobo		Hemorrhagic syndrome	Crimea Congo Virus			1 case	Cirulation of crimean congo virus in Ivory Coast [19] [20] .
39	2020	Influenza and respiratory virus	pandemic		corona virus	corona virus			More than 1 million direct debits	This pandemic has put all the economic and health systems of the countries of the world to the test. Several works have been carried out [21] [22] .
40	2020	Bacterial meningitis	national		Diagnostic test	Neisseria meningitidis			1 trial	Validation of a new immunochromatographic test (MeningoSpeed, BioSpeedia, France) for the detection and clustering of Neisseria meningitidis [23] .