Parameter

Effect

Skin vitality

Significant improvement in elastic tissue content (after 8 weeks) [73] .

Inhibition of lipoxygenase, metalloproteinase-2, hyaluronidase, and collagenase [74] [75] .

Strong antioxidant capacity, demonstrated by in vivo studies [76] [77] [78] .

Improvement in erythema and telangiectasias after 12 months [79] .

Suppression of melanin production via inhibition of tyrosinase and tyrosinase-related protein-2 activities [75] .

UV protection

Protection of skin against harmful UV radiation and helped to improve overall skin quality (in terms of elasticity, roughness, scaling, density, and water homeostasis; results evaluated after 12 weeks) [80] .

Dose-dependently reduce UVR induced cells DNA damage in fibroblasts and keratinocytes cell cultures [81] .

Others

(inflammation and body composition)

Inhibition of adipogenesis (shown in cell lines, animal models, and humans) [82] .

Reduction in body fat, systolic blood pressure, and low-density lipoprotein cholesterol (after 12 weeks) [83] .

Increasing energy expenditure via thermogenesis, fat oxidation, and fecal lipid excretion [84] .

Attenuation of the development of obesity, symptoms associated with the metabolic syndrome, and fatty liver (after 16 weeks), via decreased lipid absorption and decreased inflammation [85] .

Downregulation of over 100 genes related to tissue inflammatory responses [86] .