Compounds

In vitro Cytotoxicity IC50 (µg/ml)

X

R

HCT-116

Hela

PC3

MCF-7

CA-4

10.5 ± 0.73

9.4 ± 0.61

20.2 ± 1.12

5.3 ± 0.42

4a

CH₂

58.7 ± 3.65

61.9 ± 3.42

53.0 ± 2.98

55.4 ± 3.11

4b

N-CH₃

27.6 ± 1.98

20.1 ± 1.60

26.2 ± 1.82

17.1 ± 1.64

5a

40.8 ± 2.73

33.5 ± 2.06

41.6 ± 2.21

37.5 ± 2.30

5b

Ph

8.6 ± 0.51

8.2 ± 0.73

12.7 ± 0.88

6.9 ± 0.51

5c

COCH₃

83.8 ± 4.73

>100

>100

84.9 ± 3.99

6a

CH₃

22.6 ± 1.87

14.9 ± 1.23

17.7 ± 1.41

14.0 ± 1.41

6b

C₂H₅

29.3 ± 2.11

38.9 ± 2.25

28.5 ± 1.69

20.4 ± 1.85

6c

C₃H₇

19.8 ± 1.50

16.0 ± 1.32

18.9 ± 1.39

13.8 ± 1.42

7

63.4 ± 3.98

72.6 ± 3.83

74.5 ± 3.85

62.3 ± 3.35

8

52.6 ± 3.32

80.4 ± 4.05

65.8 ± 3.37

51.1 ± 2.89

9

70.6 ± 4.52

94.1 ± 4.53

97.3 ± 4.60

80.1 ± 3.74

10a

CH₂

35.3 ± 2.24

50.5 ± 2.89

46.7 ± 2.38

31.8 ± 2.15

10b

N-CH₃

92.9 ± 4.95

>100

93.1 ± 4.12

89.5 ± 4.32

11a

CH₂

96.4 ± 5.24

86.0 ± 4.19

82.9 ± 3.93

>100

11b

N-CH₃

65.4 ± 4.21

69.4 ± 3.60

50.9 ± 2.72

77.8 ± 3.58

12a

H

34.1 ± 2.36

46.1 ± 2.61

36.0 ± 1.94

27.1 ± 1.97

12b

CH₃

45.2 ± 2.92

25.9 ± 1.87

20.0 ± 1.47

39.9 ± 2.52

13

14.4 ± 1.05

11.4 ± 0.98

15.6 ± 1.20

9.1 ± 1.10

14

47.1 ± 3.14

57.1 ± 3.18

71.3 ± 3.65

45.6 ± 2.64

15

10.8 ± 0.92

9.5 ± 0.84

13.7 ± 0.97

8.8 ± 0.93

16

9.0 ± 0.68

7.8 ± 0.42

12.2 ± 0.81

7.9 ± 0.68

17

17.4 ± 1.32

13.1 ± 1.10

16.3 ± 1.36

10.7 ± 1.23