|
| Clinical presentation | Antiviral initiation | HSV type | Acute CNS complication | Neurologic outcome [reference] |
| At birth/boy | Mucocutaneous lesions | 4 days/yes | 2 | NA | Developmental delay, quadriplegia [13] |
| At birth/boy | Lethargy, mucocutaneous vesicles | 15 days/no | 2 | Necrotizing retinitis | Death-cause was not specified [14] |
| At birth/girl | Skin lesions and severe jitteriness | NA | 2 | Seizures, apnea, abnormal posture | Died-increased seizures, otherwise cause not specified [15] |
| At birth/boy | Generalized seizures, Lethargy, Full anterior fontanelle | NA | 2 | Large and tiny hemorrhages in cerebellar hemispheres | Died-supportive care discontinued due to poor prognosis [16] |
| 2 hours/boy | Focal seizures and Apnea | 18 hours/yes | 2 | Encephalomalacia | Died; due to fulminant necrotizing enterocolitis [17] |
| 2 days/boy | Lethargy, Apnea, and hypopnea | 4.5 hours/yes | 2 | NA | No sequelae [18] |
| 7 days/girl | Clonic jerking of right side | 2 days/yes | 1 | Recurrent Obstructive hydrocephalus | Ventriculostomy needed three times [19] |
| 9 days/girl | Vesicles on occipital and parietal scalp | <1 day/yes | 1 | None | No sequelae [20] |
| 9 days/girl | Apnea, bradycardia, and encephalitis | <1 day/yes | 1 | Left parietal Encephalomalacia with hemorrhagic component | Seizures and significant developmental delay [20] |
| 9 days/girl | Seizures | 4 days/yes | 2 | NA | Developmental delay and quadriplegia |
| 10 days/girl | Pustular rashes over the eyelid and encephalitis | <6 hours/yes | 2 | NA | No sequelae [13] |
| 10 days/girl | Apnea, lethargy, encephalitis | 5 days/yes | 2 | Recurrent Herpes simplex virus encephalitis | Oromotor dysfunction, extensor posturing, and axial hypotonia [18] |
| 13 days/girl | Generalized myoclonic seizures, lethargy | 7 days/yes | 2 | Cerebral malakoplakia | Death-secondary to chronic meningoencephalitis [21] |
| 14 days/girl | Seizures, flaccid paralysis, left ptosis. | 2 days/yes | 2 | Spastic right hemiplegia, chorioretinitis, homonymous hemianopia | Microcephaly, multi-cystic encephalomalacia [22] |
| 15 days/girl | Focal seizures, apneic episodes | 3 days/yes | 2 | Megacystic encephalomalacia, Cortical atrophy and Subdural effusions | Developmental delay, hypertonicity, and microcephaly [17] |
| 15 days/girl | Seizures | <1 day/yes | 1 | NA | Developmental delay, quadriplegia [13] |
| 16 days/girl | Lethargy, Facial diplegia, and Hypotonia | 1 day/yes | 2 | Hypotonia, and Hyperreflexia | Developmental delay, hypertonia, and hyperreflexia [23] |
| 17 days/girl | Focal clonic upper limb seizures | 2 days/yes | 1 | Acute retinal necrosis | Poor vision in the left eye [24] |
| 17 days/girl | Seizures and mucocutaneous lesions | 2 days/yes | 2 | NA | Developmental delay, and quadriplegia [13] |