primary (n = 27)

pre-ctDNA (n = 13)

PIK3CA

PIK3CA

WT

mut

P

WT

mut

P

<75 y.o.

7

5

ns#

3

2

ns

>75 y.o.

7

8

6

2

IDC*

13

11

ns

8

3

ns

ILC**

1

1

1

1

T1

6

5

ns

3

2

ns

T2-T3

8

8

6

2

N0

10

9

ns

7

2

ns

N1

4

4

2

2

PgR+

10

8

ns

6

2

ns

PgR-

4

5

3

2

Ki-67 < 20%

8

7

ns

4

3

ns

Ki-67 > 20%

6

6

5

1

HER2−***

13

9

ns

7

2

ns

HER2+***

1

4

2

2

luminal A-like

7

5

ns

3

1

ns

luminal B-like

6

7

6

2

luminal type

13

12

ns

9

3

ns

HER2-enriched type

1

1

0

1