| Primary tumor |
Pre-surgery ctDNA |
Post-surgery ctDNA |
|||||||||||||||
| Case No. |
Age |
Histological type* |
TNM** |
Stage |
ER |
PgR |
HER2*** |
Ki-67 |
Molecular subtype |
PIK3CA |
Fractional abundance |
PIK3CA |
Fractional abundance |
PIK3CA |
Fractional abundance |
||
| 1 |
55 |
IDC |
T2N0 |
IIA |
positive |
negative |
positive |
25% |
luminal B |
E542K |
1.6% |
wild-type |
wild-type |
||||
| 2 |
76 |
ILC |
T3N1 |
IIIA |
positive |
negative |
negative |
<10% |
luminal B |
E545K |
11.0% |
wild-type |
wild-type |
||||
| 3 |
51 |
IDC |
T2N0 |
IIA |
positive |
positive |
negative |
12% |
luminal A |
E545K |
22.6% |
wild-type |
wild-type |
||||
| 4 |
79 |
IDC |
T2N0 |
IIA |
positive |
negative |
negative |
35% |
luminal B |
E545K |
16.2% |
wild-type |
wild-type |
||||
| 5 |
78 |
IDC |
T2N1 |
IIB |
positive |
negative |
negative |
6% |
luminal B |
E545K |
13.1% |
E545K |
0.20% |
wild-type |
|||
| 6 |
75 |
IDC |
T1cN0 |
IA |
positive |
positive |
positive |
>50% |
luminal B |
H1047R |
43.6% |
H1047R |
0.54% |
wild-type |
|||
| 7 |
47 |
ILC |
T3N1 |
IIIA |
positive |
positive |
negative |
15% |
luminal A |
H1047R |
31.0% |
H1047R |
0.96% |
H1047R |
0.30% |
||
| 8 |
65 |
IDC |
T1bN0 |
IA |
negative |
negative |
positive |
9% |
HER2 |
H1047R |
10.2% |
H1047R |
1.08% |
H1047R |
0.27% |
||
| 9 |
85 |
IDC |
T1cN0 |
IA |
positive |
positive |
negative |
22% |
luminal B |
H1047R |
32.5% |
wild-type |
wild-type |
||||
| 10 |
79 |
IDC |
T2N1 |
IIB |
positive |
positive |
negative |
50% |
luminal B |
H1047R |
2.2% |
wild-type |
wild-type |
||||
| 11 |
75 |
IDC |
T2N0 |
IIA |
positive |
positive |
positive |
50% |
luminal B |
H1047R |
26.9% |
wild-type |
wild-type |
||||
| 12 |
84 |
IDC |
T1cN0 |
IA |
positive |
positive |
negative |
6% |
luminal A |
E542K |
3.8% |
wild-type |
wild-type |
||||
| H1047R |
22.5% |
wild-type |
wild-type |
||||||||||||||
| 13 |
39 |
IDC |
T1cN0 |
IA |
positive |
positive |
negative |
12% |
luminal A |
H1047R |
5.3% |
wild-type |
not collected |
||||
| 14 |
79 |
IDC |
T1cN0 |
IA |
positive |
positive |
negative |
16% |
luminal A |
wild-type |
|||||||
| 15 |
56 |
IDC |
T1cN1 |
IIA |
positive |
positive |
negative |
22% |
luminal B |
wild-type |
|||||||
| 16 |
81 |
IDC |
T2N0 |
IIA |
negative |
negative |
positive |
>50% |
HER2 |
wild-type |
|||||||
| 17 |
76 |
IDC |
T1cN0 |
IA |
positive |
positive |
negative |
11% |
luminal A |
wild-type |
|||||||
| 18 |
31 |
IDC |
T2N0 |
IIA |
positive |
positive |
negative |
12% |
luminal A |
wild-type |
|||||||
| 19 |
77 |
IDC |
T1cN0 |
IA |
positive |
positive |
negative |
<10% |
luminal A |
wild-type |
|||||||
| 20 |
47 |
IDC |
T1aN0 |
IA |
positive |
positive |
negative |
10% |
luminal A |
wild-type |
|||||||
| 21 |
63 |
IDC |
T2N1 |
IIB |
positive |
negative |
negative |
13% |
luminal B |
wild-type |
|||||||
| 22 |
51 |
IDC |
T2N0 |
IIA |
positive |
positive |
negative |
25% |
luminal B |
wild-type |
|||||||
| 23 |
80 |
IDC |
T2N1 |
IIB |
positive |
positive |
negative |
25% |
luminal B |
wild-type |
|||||||
| 24 |
83 |
special type |
T2N0 |
IIA |
positive |
negative |
negative |
12% |
luminal B |
wild-type |
|||||||
| 25 |
59 |
IDC |
T1cN1 |
IIA |
positive |
negative |
negative |
8% |
luminal B |
wild-type |
|||||||
| 26 |
44 |
IDC |
T2N0 |
IIA |
positive |
positive |
negative |
22% |
luminal B |
wild-type |
|||||||
| 27 |
75 |
IDC |
T2N0 |
IIA |
positive |
positive |
negative |
22% |
luminal B |
wild-type |
|||||||