| ADE (incidence %) | References | ||||||||||||||
| Cantore38 | Ignatiadis41 | Boeck42 | Kulke16 | Pelzer30 | Burzynski | ||||||||||
| Grades | Grades | Grades | Grades | Grades | Grades | ||||||||||
| 2 | 3 | 4 | 2 | 3 | 4 | 2 | 3 | 4 | 2 | 3 | 2 | 3 | 2 | 3 | |
| General |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Fatigue | 10 |
|
| 19 | 4 |
| 4 |
|
| 37 | 3 |
|
|
|
|
| Fever | 13 |
|
| 4 |
|
|
|
|
|
|
|
|
|
|
|
| Infection |
|
|
|
|
|
| 6 | 6 |
|
|
|
|
|
|
|
| Hematologic |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Hemoglobin | 23 |
|
| 11 |
|
| 10 | 2 | 2 | 13 |
| 48 |
|
|
|
| Leukopenia | 10 | 3 | 3 |
|
|
| 11 | 10 | 6 | 3 |
|
|
| 7 | 14 |
| Neutropenia | 3 | 3 |
| 11 | 19 | 15 | 4 | 13 | 4 | 3 | 7 |
|
|
| 7 |
| Thrombocytopenia | 3 | 3 |
|
|
|
| 6 | 4 | 2 |
|
| 9 |
| 7 | 14 |
| Gastrointestinal |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Abdominal pain |
|
|
|
|
|
| 6 | 4 |
|
|
|
|
|
|
|
| Anorexia |
|
|
|
|
|
|
|
|
| 17 |
|
|
|
|
|
| Constipation |
|
|
|
|
|
|
|
|
| 3 |
|
|
|
|
|
| Diarrhea | 37 | 3 |
| 8 | 8 |
| 10 | 4 |
| 37 | 17 | 4 | 9 | 7 |
|
| Dysgeusia |
|
|
|
|
|
|
|
|
| 7 |
|
|
|
|
|
| Dyspepsia |
|
|
|
|
|
|
|
|
|
|
|
|
| 7 |
|
| Mucositis |
|
|
|
|
|
| 4 |
|
| 20 | 10 |
|
|
|
|
| Nausea/vomiting | 47 |
|
| 4 |
|
| 6 |
|
| 13 | 10 | 17 | 4 | 21 |
|
| Cardiovascular |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Hypertension |
|
|
|
|
|
|
|
|
|
|
|
|
| 7 |
|
| Edema |
|
|
|
|
|
|
|
|
| 3 |
|
|
|
|
|
| Neurologic |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Paresthesia | 6 | 6 |
|
|
|
|
|
|
|
|
| 4 |
|
|
|
| Pruritus |
|
|
|
|
|
|
|
|
| 7 |
|
|
|
|
|
| Dermatologic |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Hand-foot syndrome |
|
|
|
|
|
|
|
|
| 17 | 13 |
|
|
|
|
| Rash |
|
|
| 11 |
|
| 4 | 2 |
| 17 | 13 |
|
|
|
|