Geometry

R1

(µm)

R0

(µm)

Initial slope

(association)

Initial slope

(dissociation)

Enhancement

factor*

(association)

Enhancement

factor*

(dissociation)

Original geometry

100

50

1.76 × 10−11

−5.67 × 10−12

-

-

Optimized geometry 1

70

8

1.86 × 10−11

−6.30 × 10−12

1.05

1.11

Optimized geometry 2

60

90

1.97 × 10−11

−6.50 × 10−12

1.12

1.15

Optimized geometry 3

40

110

2.1 × 10−11

−6.81 × 10−12

1.19

1.20