1) There are no fundamental laws of biology used to model health and disease. Biology, lingering in observation, is not a science [8] .

2) There is only one Cell. Subspecialty silos partition cardiovascular drugs, cancer therapies, and diabetes drugs failing to acknowledge that there is only one cell. Therefore, drugs in one discipline may have used in other disciplines that are undiscovered.

3) Biological system noise is dismissed. Carrier proteins that in themselves have no biologic activity can allow proteins to fold in a preferred manner permitting function, partially block a receptor, or the misfolded proteins lead to a serious disease [9] .

4) Using surrogate risk factors for biological measured defects is inefficient and does not account for individual compensation. Biological biomarker measures should select patients for drug therapies to increase the efficiency of studies. Some biologic markers are pivotal representing a major shift in biologic balance identifying disease and treatment of disease.

5) Inflammation is a term explaining all chronic disease states. Inflammation can increase or decrease entropy. The state of the immune system that perpetuates these states is not measured. Knowledge to characterize immune system malfunction is necessary.

6) Drugs in normal subjects may not behave the same as in diseased states due to disease activation of genes that are not present in normal subjects.

7) The study of energetics in protein folding, molecular interactions, and influence of the electromagnetic environment on protein formation is in its infancy, complex, and poorly organized.