Gene

Site

Biological effect

Ethnic characteristics

TRIM65

rs3744028

Innate immunity, apoptosis

Europe [79]

TRIM47

rs3744017

Europe [79]

rs1055129

WBP2

rs11869977

Inflammatory response

Europe [79]

rs936393

Transcriptional regulation

COX-2

rs689466

Inflammatory reaction

African American, Brazil [87]

ApoE

rs7412

Regulating blood lipid

Denmark, France, Pittsburgh [72]

rs42935

[88]

ε2, ε3, ε4

[89]

ε2, ε3, ε4

[90]

ε4

Europe [91] [92] [93]

ε2, ε4

Europe [94]

Claudin-1

rs9290927

Composition of blood brain barrier

The Republic of Korea [95]

AQP-4

rs9951307

Integrity and function of blood brain barrier

The Republic of Korea [96]

NOTCH3

rs1043994

Vascular smooth muscle hyperplasia

Europe [83]

rs10404382

rs10423702

rs1043997

CETP

rs1800775

Germany [97]

ACE

rs1799752

Regulation of systolic blood pressure and blood flow velocity

UK (white) [68] [98]

rs4646994

[90]

AGT

rs699

Australia, Rotterdam [73] [99]

AGTR1

rs5186

The Therlands, Rotterdam [73] [100]

America (White) [101] [102]

AGTR2

C3123A

America (White) [102]

CYP11B

rs1799998

France [103]

F3

rs3917643

Regulation of coagulation function

USA (Non Hispanic White) [78]

MTHFR

rs1801133

DNA and RNA biosynthesis

Japan, Hungary, USA [104]

rs1801131

[101] [105]

IL-6

rs1800795

Immune and inflammatory response

America (White) [74]

IL-10

rs1800896

India, Greece, Italy [106]

IL5RA

rs2290608

Spain (White) [75]

ITGB6

rs1049721

Spain (White) [75]

CAPN10

rs7571442

USA (Non Hispanic White) [78]

NR3C1

rs6190

Netherlands [107]

SH3PXD2A

rs12357919

Inflammatory reaction and gliosis

Europe, African American, Spain, Asia [108]

SH3PXD2A

rs7909791

EFEMP1

rs78857879

HAAO

rs11679640

KITLG

rs995029

Proliferation of vascular endothelial cells

USA (Non Hispanic White) [78]

BDNF

rs6265

Nerve regeneration

America [76]

Taiwan, China [109]

America (White) [101]

MMP2

rs9928731

Neuroinflammatory reaction

USA (Non Hispanic White) [78]

MMP3

rs679620

Non Hispanic White [77]

MMP9

rs2250889

Non Hispanic White [77]

MMP13

rs2252070

Spain [75]

ICAM1

rs5498

Cytoskeleton and cell adhesion

Europe [79]

KLC1

rs8702

Hungary [110]

ADD1

rs4961

Regulating ion transport and sodium pump

Rotterdam [111]

A2M

rs669

Regulating cerebral blood flow

Spain (White) [75]

PON1

rs854560

Oxidative stress

Australia, Chile [112]

rs662

[73] [113]

NOS3

rs1799983

Netherlands, Spain (White) [100]

rs1800779

[75]

FOXF2

rs12204590

Lack of differentiation of vascular parietal cells

Europe [114]