LncRNA | Target gene | Major methods and subject | Role or function | Cataract classification | reference |
KCNQ1OT1↑ | SMAD4 | TGF-β2 induced SRA01/02 in vitro | HLECs proliferation and EMT | ASC and PCO | [31] |
KCNQ1OT1↑ | MiR-214/caspase-1 | induced SRA01/04 cell in vitro | Promote HLECs Pyroptosis, | ARC | [12] |
FEZF1-AS1↑ | FEZF1 | induced SRA01/04 cell in vitro | Promote HLECs proliferation | PCO | [39] |
MIAT↑ | MiRNA-150-5p/Akt | SRA01/04 cell in vitro | Increase HLECs proliferation and viability; decrease HLECs dead or dying | PCO | [34] |
H19↑ | miRNA-675-5p | HECs in vitro | Increase HLECs proliferation and migration, decrease HLECs dead or dying | Nuclear cataract | [33] |
H19↑ | miR-29 | HECs in vitro | Increase HLECs proliferation and migration, decrease HLECs apoptosis | ARC | [36] |
TUG1↑ | MiRNA-214 | HECs in vitro | Promote HLECs apoptosis, | cataract | [37] |
MALAT1↑ | P38 | HECs in vitro | Promote HLECs apoptosis | Diabetic cataract | [32] |
PLCD3-OT1↓ | MiR-224-5P | induced SRA01/04 cell in vitro | Inhibit HLECs apoptosis | ARC | [38] |