Baseline | 15 min | 30 min | 45 min | 60 min | 90 min | 120 min | iAUC | GI | |
Phase 1 | |||||||||
A1 | 79.2* (7.07) | 87.9 (9.12) | 95.8 (7.44) | 90.1 (14.19) | 88.7 (14.64) | 84.7 (9.1) | 79.5 (7.17) | 1008 (187) | 34 (6) |
B1 | 78.2* (7.11) | 98 (14.22) | 116.9 (12.24 | 105.7 (17.26) | 94.2 (17.21) | 79.8 (11.16) | 74.6 (9.51) | 1820 (207) | 63 (7) |
R1 | 81.0 (5.99) | 109.0 (11.30) | 137.1 (13.61) | 129.5 (14.85) | 114.6 (18.51) | 86.2 (12.91) | 69.3 (6.64) | 2997 (257) | - |
p-value* | 0.457 | <0.001 | <0.001 | <0.001 | <0.001 | 0.204 | 0.001 | <0.001 | - |
p-value** (A1 vs B1) | 0.542 | 0.016 | <0.001 | <0.001 | 0.073 | 0.024 | 0.049 | <0.001** | 0.002** |
Phase 2 | |||||||||
A2 | 78.7 (5.69) | 90.8 (12.62) | 95.7 (13.63) | 89.9 (14.1) | 86.8 (12.36) | 85.1 (9.93) | 78.6 (7.67) | 1111 (161) | 32 (5) |
B2 | 78.8 (8.03) | 94.3 (11.82) | 105.8 (10.92) | 92.6 (11.46) | 86.8 (10.12) | 84.3 (7.72) | 78.4 (6.31) | 1260 (166) | 37 (4) |
C2 | 72.7 (8.89) | 81.8 (10.02) | 90.4 (10.78) | 93.3 (9.36) | 91.1 (9.80) | 80.7 (5.17) | 76.3 (8.79) | 1076 (190) | 31 (5) |
D2 | 81.5 (4.98) | 91.6 (10.97) | 95.4 (8.30) | 88.9 (9.43) | 84.4 (6.82) | 82.5 (4.90) | 77.1 (6.79) | 1076 (190) | 31 (5) |
E2 | 77.6 (7.93) | 94.9 (16.35) | 108.3 (18.65) | 105.3 (14.76) | 98.8 (15.02) | 81.6 (10.19) | 76.8 (6.53) | 1890 (187) | 55 (4) |
R2 | 77.9 (6.63) | 103.6 (14.24) | 134.5 (14.31) | 134.6 (19.46) | 120.6 (21.78) | 92.4 (14.06) | 70.9 (7.51) | 3516 (1244) | - |
p-value* | 0.152 | 0.002 | <0.001 | <0.001 | <0.001 | 0.009 | 0.014 | <0.001 | - |