Baseline

15 min

30 min

45 min

60 min

90 min

120 min

iAUC

GI

Phase 1

A1

79.2* (7.07)

87.9 (9.12)

95.8 (7.44)

90.1 (14.19)

88.7 (14.64)

84.7 (9.1)

79.5 (7.17)

1008 (187)

34 (6)

B1

78.2* (7.11)

98 (14.22)

116.9 (12.24

105.7 (17.26)

94.2 (17.21)

79.8 (11.16)

74.6 (9.51)

1820 (207)

63 (7)

R1

81.0 (5.99)

109.0 (11.30)

137.1 (13.61)

129.5 (14.85)

114.6 (18.51)

86.2 (12.91)

69.3 (6.64)

2997 (257)

-

p-value*

0.457

<0.001

<0.001

<0.001

<0.001

0.204

0.001

<0.001

-

p-value**

(A1 vs B1)

0.542

0.016

<0.001

<0.001

0.073

0.024

0.049

<0.001**

0.002**

Phase 2

A2

78.7 (5.69)

90.8 (12.62)

95.7 (13.63)

89.9 (14.1)

86.8 (12.36)

85.1 (9.93)

78.6 (7.67)

1111 (161)

32 (5)

B2

78.8 (8.03)

94.3 (11.82)

105.8 (10.92)

92.6 (11.46)

86.8 (10.12)

84.3 (7.72)

78.4 (6.31)

1260 (166)

37 (4)

C2

72.7 (8.89)

81.8 (10.02)

90.4 (10.78)

93.3 (9.36)

91.1 (9.80)

80.7 (5.17)

76.3 (8.79)

1076 (190)

31 (5)

D2

81.5 (4.98)

91.6 (10.97)

95.4 (8.30)

88.9 (9.43)

84.4 (6.82)

82.5 (4.90)

77.1 (6.79)

1076 (190)

31 (5)

E2

77.6 (7.93)

94.9 (16.35)

108.3 (18.65)

105.3 (14.76)

98.8 (15.02)

81.6 (10.19)

76.8 (6.53)

1890 (187)

55 (4)

R2

77.9 (6.63)

103.6 (14.24)

134.5 (14.31)

134.6 (19.46)

120.6 (21.78)

92.4 (14.06)

70.9 (7.51)

3516 (1244)

-

p-value*

0.152

0.002

<0.001

<0.001

<0.001

0.009

0.014

<0.001

-