Parameters

Reference drug

Test drug

AUC_t (μg∙h/mL)

20.54 ± 4.30

18.42 ± 2.96

AUC_∞ (μg∙h/mL)

21.22 ± 4.38

19.14 ± 3.06

Extrapolated AUC (%)

3.22 ± 1.05

3.75 ± 1.73

AUMC_t (μg∙h²/mL)

35.34 ± 13.56

28.56 ± 7.88

AUMC_∞ (μg∙h²/mL)

39.93 ± 15.37

33.47 ± 9.19

Vd (L)

36.68 ± 11.25

45.18 ± 20.68

MRT (h)

1.86 ± 0.39

1.73 ± 0.29

C_max (μg/mL)

12.69 ± 3.27

12.81 ± 2.80

T_1/2α (h)

0.29 ± 0.15

0.40 ± 0.27

T_max (h)

1.22 ± 0.57

0.92 ± 0.32

k_α (h⁻¹)

3.23 ± 2.64

2.46 ± 1.58

T_1/2β (h)

1.02 ± 0.31

1.13 ± 0.57

λ_z (k_e, h⁻¹)

0.73 ± 0.17

0.69 ± 0.19

CL (L/h)

25.36 ± 5.26

27.83 ± 4.57