| dHACM/dHCM | Flaps/tissue transfers | Prostheses |
|
| Advantages |
|
| *Concurrent NPWT aids tissue regeneration and moisture management | No Immunologic products; autologous tissue used | Different types of prostheses available |
| Extremities retained | Immediate wound coverage with placement | Artificial limb or appendage |
| No other body parts used for healing or reconstruction | Potentially shorter LOS | Potentially shorter LOS |
| Improved Quality of Life |
| Treatment occurs out of hospital |
| Treatment easily transferred to outpatient setting |
| Wheelchair alternative |
|
| Disadvantages |
|
| Direct wound visualization is not possible while NPWT drape is in place. | NPWT cannot be applied over flap or tissue transfer; tissue regeneration and healing have no NPWT benefits. | Expensive acquisition costs |
| If NPWT applied improperly over healthy skin, it may lead to skin trauma or breakdown | Loss of a body part (muscle, skin) to cover wound; functional disability (walking; lifting oneself) due to lost muscle or skin | Increased lifelong expenses and healthcare maintenance |
|
| Treatment cannot be transitioned to the outpatient setting until healing occurs | Impaired Quality of Life |