Efflux pumps families

Efflux pumps genes and (regulators)

Energy resource

Substrates

RND

adeABC

(adeSR, baeSR)

Proton motive force (H+)

Aminoglycosides, Benzalkonium Chloride, Β-Lactams, Tetracycline, Chloramphenicol, Deoxycholate, Ethidium Bromide, Erythromycin, Tigecycline Fluoroquinolones, Nalidixic Acid, Methyl Viologen, Sodium Dodecyl Sulfate.

adeAA2B (baeSR)

Tigecycline

adeFGH (adeL)

Sodium Dodecyl Sulfate, Tetracycline, Tigecycline, Nalidixic Acid, Sulfonamides, Ethidium Bromide, Fluoroquinolones, Erythromycin.

adeIJK (adeN,

baeSR)

Azithromycin, Benzalkonium Chloride, Β-Lactams, Farnesol, Chloramphenicol, Clindamycin, Crystal Violet, Deoxycholate, Fusidic Acid, Erythromycin, Fluoroquinolones, Minocycline, Nalidixic Acid, Rifampicin, Sodium Dodecyl Sulfate, Triclosan, Tetraphenylphosphonium, Trimethoprim, Tetracycline.

MFS

craA

Proton motive force (H+)

Chloramphenicol

cmlA

Chloramphenicol

floR

Chloramphenicol, Florfenicol

tetA(B) (tetR)

Tetracycline

MATE

abe M

Proton motive force (Na+/H+)

Acrifl Avine, 6-Diamidine-2-Phenylindole, Daunomycin, Doxorubicin, Fluoroquinolones, Gentamicin, Rhodamine 6G, Tetracycline.

SMR

abeS

Proton motive force (H+)

Acridine Orange, Acrifl Avine, Benzalkonium Chloride, Β-Lactams, Chloramphenicol, Ciprofl Oxacin, Deoxycholate, Ethidium Bromide, Tetraphenylphosphonium, Erythromycin, Novobiocin, Sodium Dodecyl Sulfate,

Smr (A1S_0710)

Deoxycholate, Sodium Dodecyl Sulfate

ABC

macAB-tolC (baeSR)

ATP hydrolysis

(P-gp)

Erythromycin, Gramicidin

PACE

aceI

Proton motive force (H+)

Chlorhexidine

Acinetobacter Genospecies 3

RND

adeDE

Proton motive force (H+)

Ceftazidime, Amikacin, Ciprofloxacin, Chloramphenicol, Erythromycin, Ethidium Bromide, Meropenem, Rifomycin, Tetracycline

RND

adeXYZ

Β-Lactams, Ciprofloxacin, Tetracycline, Rifampin, Chloramphenicol