Variable

First dose

p

Second dose

p

Out of restriction

%

Within restriction

%

Out of restriction

%

Within restriction

%

Abdominal pain

1

16.6

15

17.6

>0.05

1

12.5

11

17.4

<0.05

Vomit

2

33.3

24

28.2

>0.05

2

25

19

30.1

>0.05

Fever

1

16.6

18

21.1

>0.05

2

25

15

23.8

>0.05

Purpura

1

16.6

5

5.8

<0.05

1

12.5

4

6.3

<0.05

Polipnea

1

16.6

8

9.4

<0.05

1

12.5

6

9.5

>0.05

Diarrhea

1

16.6

11

12.9

>0.05

1

12.5

8

12.6

>0.05

Bloody stools

1

16.6

2

2.35

<0.05

1

12.5

2

3.1

<0.05

Irritability

1

16.6

14

16.4

>0.05

2

25

11

17.4

<0.05

Rhinorrhea

1

16.6

5

5.8

<0.05

1

12.5

4

6.3

<0.05

Dehydration

1

16.6

11

12.9

>0.05

1

12.5

9

14.2

>0.05