Characteristics

AUC24

(n = 17)

Trough

(n = 30)

P-value (98% Confidence Interval)

Demographic

Age (years) (median IQR)

63.5 (61, 66)

71.5 (70, 73)

0.3

Weight (kg)

76

56

Female No. (%)

9 (50)

11 (37)

0.3

Comorbidities

Diabetes (%)

3 (17)

5 (17)

0.9

COPD (%)

0

7 (23)

0.03

CKD (%)

2 (11)

2 (7)

0.5

Malignancy (%)

3 (17)

3 (10)

0.5

HIV (%)

3 (17)

3 (10)

0.5

Pneumonia

1

10

0.03

Bloodstream

3

6

0.8

Soft skin and tissue

9

7

0.04

Osteomyelitis

2

6

0.5

Central nervous system (CNS)

0

0

Endocarditis

0

0

Diabetic foot

1

0

0.2

Septic shock

0

1

0.2

Intra-abdominal

1

0

0.2

Medications

ICU/Vasopressor prior vancomycin (%)

2 (11.8)

4 (13.3)

0.5

ICU/Vasopressor post vancomycin (%)

2 (12)

1 (3)

0.3

Concomitant anti-infectives (%)

16 (89)

22 (73)

0.08

Concomitant nephrotoxic agent (%)

12 (67)

21 (70)

1.0