Characteristics | AUC24 (n = 17) | Trough (n = 30) | P-value (98% Confidence Interval) | |
Demographic | Age (years) (median IQR) | 63.5 (61, 66) | 71.5 (70, 73) | 0.3 |
Weight (kg) | 76 | 56 |
| |
Female No. (%) | 9 (50) | 11 (37) | 0.3 | |
Comorbidities | Diabetes (%) | 3 (17) | 5 (17) | 0.9 |
COPD (%) | 0 | 7 (23) | 0.03 | |
CKD (%) | 2 (11) | 2 (7) | 0.5 | |
Malignancy (%) | 3 (17) | 3 (10) | 0.5 | |
HIV (%) | 3 (17) | 3 (10) | 0.5 | |
Pneumonia | 1 | 10 | 0.03 | |
Bloodstream | 3 | 6 | 0.8 | |
Soft skin and tissue | 9 | 7 | 0.04 | |
Osteomyelitis | 2 | 6 | 0.5 | |
Central nervous system (CNS) | 0 | 0 |
| |
Endocarditis | 0 | 0 |
| |
Diabetic foot | 1 | 0 | 0.2 | |
Septic shock | 0 | 1 | 0.2 | |
Intra-abdominal | 1 | 0 | 0.2 | |
Medications | ICU/Vasopressor prior vancomycin (%) | 2 (11.8) | 4 (13.3) | 0.5 |
ICU/Vasopressor post vancomycin (%) | 2 (12) | 1 (3) | 0.3 | |
Concomitant anti-infectives (%) | 16 (89) | 22 (73) | 0.08 | |
Concomitant nephrotoxic agent (%) | 12 (67) | 21 (70) | 1.0 |