Studies | Study design | Country | Children exposed to ASM | Type of Antiseizure medication | ASD Diagnostic criteria of | Trimester of Exposure | NOS Quality |
Bromley, et al. 2008 [9] | Population-based cohort study | UK | 249 children | Valproic acid, lamotrigine and phenytoin | DSM-IV criteria | During pregnancy | 8 |
Christensen et al. 2013 [10] | Population-based cohort study | Denmark | 508 children | valproic acid | ICD-10 criteria | During pregnancy | 9 |
Stadelmaier et al. 2017 [11] | Population-based Case-control study | USA | 47 children | Valproic acid | ADI-R, ADOS and SCQ | First trimester | 7 |
Wiggs et al. 2020 [12] | Population-based cohort study | Sweden | 3316 children | valproic acid, lamotrigine, carbamazepine and any AEDs | ICD-10 criteria | First trimester | 8 |
Wood et al. 2015 [13] | Population-based cohort study | Australia | 105 children | valproic acid, carbamazepine and lamotrigine | DSM-IV criteria | During pregnancy | 5 |
Rasalam et al. 2017 [14] | Population-based cohort study | Scotland | 260 children | Valproic acid, Carbamazepine | DSM-IV criteria | During pregnancy | 6 |
Bjork, et al. 2022 [15] | Population-based cohort study | Denmark Finland Norway and Sweden | 24,825 children | Lamotrigine, Carbamazepine Valproate, Pregabalin, Gabapentin, Oxcarbazepine, Clonazepam, Levetiracetam, topiramate and Phenobarbital | ICD-10 criteria | During pregnancy | 9 |
Bjork, et al. 2018 [18] | Population-based cohort study | Norway | 335 children | valproate, oxcarbazepine, primidone, levetiracetam, gabapentin, Carbamazepine, clonazepam, phenobarbital, phenytoin, clobazam | M-CHAT And SCQ Criteria | First trimester | 9 |
Bromley, et al. 2013 [19] | Population-based cohort study | UK | 201 children | Valproate, lamotrigine Carbamazepine | N/A | During pregnancy | 9 |
Veiby, et al. 2013 [20] | Population-based cohort study | Norway | 333 children | Lamotrigine, valproate, oxcarbazepine, primidone, levetiracetam, gabapentin Carbamazepine, clonazepam, phenobarbital, phenytoin, clobazam | MCHAT and ESAT | During pregnancy | 8 |