| Year | ESRD-Dialysis (Number of Patients) |
| 1978 | 14,000 |
| 1986 | 32,000 |
| 1991 | ACE entered the market as a renoprotective drug |
| 1993 | Article on renoprotective effect |
| 1994 | 65,000 |
| 1998 | 75,000 |
| 2006 | 354,754 |
| 2011 | 616,000 |