Phase

Tb vaccine

Tb vaccine type

Phase I

AdAg85A

Viral vectored (Adenovirus serotype 5 expressing Ag85A)

MTBVAC

Attenuated Mycobacterium tuberculosis strain

(Attenuated M. tuberculosis clinical isolate with ESAT6 & CFP10 & independent stable genetic

deletions of phoP & fadD26 genes)

ID93 + GLA-SE

Protein/adjuvant (Fusion Rv1813, Rv2608, Rv3619, Rv3620 with GLA-SE adjuvant)

DAR 901

Mycobacterial—whole cell or extract

(Agar-grown SRL172 by scalable, broth-grown manufacturing technique)

TB/FLU-04L

Viral vectored (Attenuated replication- deficient influenza virus vector expressing antigens Ag85A & ESAT-6)

Phase IIa

VPM 1002

Recombinant BCG (rBCG vaccine with listeriolysin O encoding gene)

RUTI

Mycobacterial, whole cell or extract (Polyantigenic liposomal vaccine of detoxified, fragmented M. tuberculosis)

H56: IC31

Protein/adjuvant (Fusion protein of Ag85B, ESAT-6,

latent Rv2660c with IC31 adjuvant)

H4: IC31

Protein/adjuvant (H4 antigen, IC31 adjuvant)

MVA85A

Viral vectored (Recombinant replication-deficient modified Vaccinia virus Ankara expressing Ag85A)

M72 + AS01E

Protein/adjuvant (Fusion protein Mtb32A &

Mtb39A, AS01E adjuvant)

Phase III

Vaccae

Mycobacterial, whole cell or extract (Heat-killed M. vaccae)