Surgery +

Chemotherapy

Surgery +

Chemotherapy + Radiotherapy

Chemotherapy +

Radiotherapy

Chemotherapy

Chemotherapy +

Radiotherapy +

Targeted therapy

Target lesions

Baseline

17

4

3

43

7

1^st assessment

14

3

2

38

3

2^nd assessment

12

3

2

33

3

Non-target lesions

Baseline

16

3

2

13

2

1^st assessment

12

2

0

11

2

2^nd assessment

12

1

1

6

1

New lesions

1^st assessment

2

1

2

5

1

2^nd assessment

19

2

2

5

1