A

Inheritance, in resulting, clonal, karyotype normal fitness-gained diploid cell propagation

B

4n nucleus in perpendicular position relative to cell polarity axis, the cytoskeleton

C

4n-mother cell becomes physically withdrawn from cell-to-cell adhesion-contacts by division in a 90˚ turn relative to the cytoskeleton

D

Destruction with loss/displacement of cell adhesion proteins, E-cadherin and beta-catenin

E

Cell polarity change/loss is a cancer-associated evolutionary developing, permanent feature

F

Whole complement segregation followed by simple fission division places fitness-gained cells in a 90˚ orientation relative to surrounding tissue cells

G

Cell-freedom from contact inhibition and gain of motility

H

Original cytoskeleton in 4n-mother-cell “crushed” (destroyed) in 4n cell “apical-basal” division-system, demanding rebuilding in offspring cells

I

Cytoskeleton rebuilt in a perpendicular orientation relative to original cell axial orientation

J

Restructured cytoskeleton confers cell-polarity and cell-shape (morphology) change on clonally propagating fitness-gained cells

K

Cell axial change in “epithelial-mesenchymal-transition (EMT)” is from 90˚ 4n-skewed division-system