| Hemoglobin (g/dl) |
|
|
|
|
|
|
|
| Mean ± SD | 10.73 | ±2.29 | 11.56 | ±2.16 | 9.58 | ±2.01 | 0.009• |
| Median (Range) | 10.20 | (6.60 - 14.30) | 12.50 | (7 - 14.30) | 9.10 | (6.60 - 14) | |
| <12 g/dl | 25 | (55.6%) | 9 | (36%) | 16 | (64%) | 0.001 |
| ≥12 g/dl | 20 | (44.4%) | 17 | (85%) | 3 | (15%) | |
| LDH (U/L) |
|
|
|
|
|
|
|
| Mean ± SD | 354 | ±107.94 | 305.76 | ±89.94 | 420 | ±96.37 | 0.001• |
| Median (Range) | 340 | (190 - 540) | 300 | (190 - 500) | 440 | (210 - 540) | |
| ≤350 U/L | 23 | (51.1%) | 19 | (82.6%) | 4 | (17.4%) | 0.001 |
| >350 U/L | 22 | (48.9%) | 7 | (31.8%) | 15 | (68.2%) | |
| B2-microglobulin (mg/L) |
|
|
|
|
|
|
|
| Mean ± SD | 2.91 | ±0.99 | 2.67 | ±0.97 | 3.25 | ±0.95 | 0.046• |
| Median (Range) | 3 | (1.40 - 5) | 2 | (1.40 - 4.40) | 3.30 | (2 - 5) | |
| <3.5 mg/L | 29 | (64.4%) | 18 | (62.1%) | 11 | (37.9%) | 0.433 |
| ≥3.5 mg/L | 16 | (35.6%) | 8 | (50%) | 8 | (50%) | |
| Coomb’s test |
|
|
|
|
|
|
|
| Negative | 38 | (84.4%) | 24 | (63.2%) | 14 | (36.8%) | 0.114 |
| Positive | 7 | (15.6%) | 2 | (28.6%) | 5 | (71.4%) | |
| Lymphocytic doubling time |
|
|
|
|
|
|
|
| <12 months | 21 | (46.7%) | 18 | (85.7%) | 3 | (14.3%) | <0.001 |
| >12 months | 24 | (53.3%) | 8 | (33.3%) | 16 | (66.7%) | |
| Cytogenetic analysis |
|
|
|
|
|
|
|
| Normal | 20 | (44.4%) | 15 | (75%) | 5 | (25%) | 0.001 |
| del 13 | 4 | (8.9%) | 3 | (75%) | 1 | (25%) | |
| del 11 | 5 | (11.1%) | 1 | (20%) | 4 | (80%) | |
| Trisomy 12 | 6 | (13.3%) | 6 | (100%) | 0 | (0%) | |
| del 17 | 5 | (11.1%) | 1 | (20%) | 4 | (80%) | |
| Complex | 5 | (11.1%) | 0 | (0%) | 5 | (100%) | |
| CD38 (%) |
|
|
|
|
|
|
|
| Mean ± SD | 23.79 | ±25.41 | 11.76 | ±13.31 | 40.26 | ±28.94 | <0.001• |
| Median (Range) | 8 | (0.30 - 91.59) | 4.90 | (0.30 - 42) | 38 | (0.72 - 91.59) | |
| <30% | 28 | (62.2%) | 23 | (82.1%) | 5 | (17.9%) | <0.001 |
| >30% | 17 | (37.8%) | 3 | (17.6%) | 14 | (82.4%) | |
| MCL-1 (%) |
|
|
|
|
|
|
|
| Mean ± SD | 60.60 | ±41.98 | 49.14 | ±42.41 | 76.27 | ±36.89 | 0.087• |
| Median (Range) | 91.30 | (0.60 - 99.70) | 38.03 | (0.60 - 99.70) | 98 | (9.70 - 99.20) | |
| <25% | 18 | (40%) | 13 | (72.2%) | 5 | (27.8%) | 0.109 |
| >25% | 27 | (60%) | 13 | (48.1%) | 14 | (51.9%) | |
| BCL-2 (%) |
|
|
|
|
|
|
|
| Mean ± SD | 52.20 | ±29.24 | 46.47 | ±34.34 | 60.04 | ±18.45 | 0.223• |
| Median (Range) | 53.90 | (2 - 93.20) | 48.20 | (2 - 93.20) | 66.20 | (35.70 - 93.20) | |
| <10% | 8 | (17.8%) | 8 | (100%) | 0 | (0%) | 0.014 |
| >10% | 37 | (82.2%) | 18 | (48.6%) | 19 | (51.4%) | |
| ZAB-70 |
|
|
|
|
|
|
|
| <20% | 27 | (60%) | 11 | (40.7%) | 16 | (59.3%) | 0.005 |
| >20% | 18 | (40%) | 15 | (83.3%) | 3 | (16.7%) |