Inhibition of Keratinization (ED-50)¹

Retinoid

SoRI No.

BP-HTOC Assay

Standard HTOC Assay

t-Retinoic acid

4.0 × (E−12)

2.0 × (E−11)

13-cis-Retinoic acid

6618

1.0 × (E−11)

3.3 × (E−10)

t-4-Oxoretinoic acid

6621

4.0 × (E−11)

1.0 × (E−9)

t-Retinol

6631

3.5 × (E−10)

2.4 × (E−9)

13-cis-Retinol

6632

1.0 × (E−10)

4.0 × (E−9)

t-4-Hydroxyphenylretinamide

6612

1.5 × (E−10)

3.5 × (E−9)

14-Carboxyretinoic acid

6637

3.3 × (E−9)

1.0 × (E−8)

N-(t-Retinoyl)-leucine

6623

4.0 × (E−9)

2.0 × (E−8)

N-(t-Retinoyl)-alanine

6628

5.0 × (E−9)

2.5 × (E−8)

14-[Ethylamino)-carbonyl]-

retinoic acid

6728

1.0 × (E−8)

2.7 × (E−8)

14[(Ethylamino)-carbonyl]

13-cis retinoic acid

6727

1.0 × (E−8)

3.5 × (E−8)

N-(t-Retinoyl)phenylalanine

6729

3.5 × (E−7)

1.0 × (E−6)