| Type of adverse reaction | General group | Severe group | ||
| Worsening symptoms | General symptoms | Severe symptoms | General symptoms | |
| Leukopenia | 0 | 5 | 5 | 2 |
| Hypokalemia | 0 | 24 | 10 | 5 |
| Drug fever | 0 | 2 | 5 | 0 |
| Abnormal liver function | 0 | 14 | 5 | 1 |
| Myelosuppression | 0 | 1 | 1 | 0 |
| Rash | 0 | 3 | 0 | 2 |
| Anemia | 2 | 0 | 2 | 0 |
| Renal impairment | 0 | 38 | 5 | 5 |
| Thrombocytopenia | 0 | 0 | 1 | 0 |
| Nausea and vomiting | 0 | 7 | 0 | 3 |
| Fatigue and dizziness | 0 | 3 | 0 | 1 |
| Pruritus | 0 | 3 | 0 | 1 |
| Angina pectoris | 0 | 0 | 0 | 1 |
| Vertigo | 0 | 1 | 0 | 0 |
| Abdominal pain | 0 | 1 | 0 | 0 |
| Diarrhea | 0 | 1 | 0 | 0 |