Variables and Parameters

Descriptions

S₁

Concentration of glucose

S₂

Concentration of pool of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate

S₃

Concentration of 1,3-bisphosphoglycerate

S₄

Concentration of pool of pyruvate and acetaldehyde in cytosol

N₁

Concentration of NAD⁺

N₂

Concentration of NADH

A₂

Concentration of ADP

A₃

Concentration of ATP

, , , ,

Concentrations of coupling substances in the external solution

J₀

Input flux of glucose via the cellular membrane

k₂

Rate constant of the glyceraldehyde-3-phosphate dehydrogenase reaction

k₃

Rate constant of the lumped phosphoglyceratekinase/phosphoglyceratemutase/enolase/

pyruvate kinase reaction

k₄

Rate constant of the alcohol dehydrogenase reaction

k₅

Rate constant of non-glycolytic ATP consumption

k₆

Rate constant of the lumped reaction transforming triose phosphates into glycerol

k₇

Rate constant of pyruvate and acetaldehyde consumption

r

Rate constant of the degradation of the coupling substance within the extracellular medium

κ

Kinetic constant of the transmembrane flux of the coupling substance

q

Co-operativity coefficient of ATP inhibitation

N

Sum of the concentrations of NAD⁺ and NADH

A

Sum of the concentrations of ADP and ATP

φ

Ratio of the total cellular volume to the extracellular volume

d_F

Diffusion coefficient

f₀

Coefficient that designates the amplitude of randomization