Description | Gene markers | BRCA | ESCA | STAD | |||||||||
None | Purity | None | Purity | None | Purity | ||||||||
Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | ||
CD8+ T cell | CD8B | 0.0670 | 0.0262 | 0.0629 | 0.0474 | −0.2090 | 0.0043 | −0.2523 | ** | −0.1320 | 0.0071 | −0.1314 | 0.0104 |
T cell | CD3D | 0.1411 | *** | 0.1433 | *** | −0.0822 | 0.2662 | −0.1553 | 0.0374 | −0.0169 | 0.7321 | −0.0458 | 0.3741 |
CD3E | 0.1354 | *** | 0.1378 | *** | −0.0796 | 0.2813 | −0.1566 | 0.0358 | −0.0438 | 0.3734 | −0.0796 | 0.1221 | |
CD2 | 0.1823 | *** | 0.1911 | *** | −0.0954 | 0.1963 | −0.1620 | 0.0298 | −0.0143 | 0.7716 | −0.0430 | 0.4042 | |
B cell | CD19 | 0.1114 | ** | 0.1061 | ** | −0.1218 | 0.0986 | −0.1921 | 0.0098 | −0.1008 | 0.0402 | −0.1197 | 0.0198 |
CD79A | 0.0993 | 0.0010 | 0.0929 | 0.0034 | −0.1296 | 0.0788 | −0.1996 | 0.0072 | −0.0449 | 0.3621 | −0.0775 | 0.1321 | |
Monocyte | CD86 | 0.3261 | *** | 0.3388 | *** | 0.1881 | 0.0104 | 0.1348 | 0.0713 | 0.1766 | ** | 0.1442 | 0.0049 |
CD115 (CSF1R) | 0.1292 | *** | 0.1246 | ** | 0.1329 | 0.0714 | 0.0887 | 0.2364 | 0.0796 | 0.1052 | 0.0483 | 0.3484 | |
TAM | CCL2 | 0.2955 | *** | 0.2941 | *** | 0.2009 | 0.0061 | 0.1664 | *** | 0.1194 | 0.0149 | 0.0892 | 0.0830 |
CD68 | 0.3696 | *** | 0.3846 | *** | 0.1596 | 0.0300 | 0.1294 | *** | 0.1816 | ** | 0.1570 | 0.0022 | |
IL10 | 0.3334 | *** | 0.3457 | *** | 0.2242 | 0.0022 | 0.1972 | *** | 0.1405 | 0.0041 | 0.0939 | 0.0678 | |
M1 Marcophage | INOS (NOS2) | 0.2002 | *** | 0.1912 | *** | −0.1455 | 0.0481 | −0.1446 | *** | 0.1398 | 0.0043 | 0.1396 | 0.0065 |
IRF5 | 0.1114 | ** | 0.1127 | ** | −0.0193 | 0.7946 | −0.0515 | 0.4925 | −0.0669 | 0.1740 | −0.0760 | 0.1397 | |
PTGS2 | 0.0863 | 0.0042 | 0.0817 | 0.0100 | 0.3327 | *** | 0.3050 | *** | 0.3330 | *** | 0.3124 | *** | |
M2 Marcophage | CD163 | 0.3431 | *** | 0.3582 | *** | 0.1310 | 0.0755 | 0.0862 | 0.2498 | 0.1650 | ** | 0.1295 | 0.0116 |
VISG4 | 0.2502 | *** | 0.2605 | *** | 0.0926 | 0.2101 | 0.0507 | 0.4992 | 0.1019 | 0.0379 | 0.0684 | 0.1837 | |
MS4A4A | 0.2575 | *** | 0.2712 | *** | 0.0769 | 0.2981 | 0.0312 | 0.6773 | 0.0649 | 0.1871 | 0.0429 | 0.4048 | |
Neutrophils | CCR7 | 0.0951 | 0.0016 | 0.0948 | 0.0028 | −0.0800 | 0.2789 | −0.1502 | 0.0441 | −0.0168 | 0.7335 | −0.0452 | 0.3798 |
Natural kill cell | KIR2DL1 | 0.1538 | *** | 0.1546 | *** | −0.0530 | 0.4737 | −0.0858 | 0.2522 | 0.0187 | 0.7033 | 0.0512 | 0.3200 |
KIR2DL3 | 0.1621 | *** | 0.1576 | *** | −0.0523 | 0.4793 | −0.0638 | 0.3949 | 0.0304 | 0.5374 | 0.0580 | 0.2598 | |
KIR2DL4 | 0.2156 | *** | 0.2160 | *** | −0.0688 | 0.3521 | −0.1022 | 0.1720 | 0.1601 | 0.0011 | 0.1434 | 0.0052 | |
KIR3DL2 | 0.1214 | **1 | 0.1255 | ** | −0.0183 | 0.8045 | −0.0524 | 0.4844 | −0.0163 | 0.7400 | −0.0115 | 0.8238 | |
KIR3DL3 | 0.0890 | 0.0031 | 0.0917 | 0.0038 | −0.0435 | 0.5562 | −0.0549 | 0.4641 | 0.0582 | 0.2369 | 0.0847 | 0.0998 | |
KIR2DS4 | 0.1701 | *** | 0.1744 | *** | 0.0465 | 0.5294 | 0.0162 | 0.8296 | 0.0457 | 0.3529 | 0.0693 | 0.1782 | |
Dendritic cell | HLA-DPB1 | 0.0541 | 0.0729 | 0.0371 | 0.2423 | −0.0373 | 0.6143 | −0.0999 | 0.1819 | −0.0125 | 0.7995 | −0.0451 | 0.3815 |
HLA-DQB1 | 0.1394 | *** | 0.1317 | *** | −0.1081 | 0.1429 | −0.1588 | 0.0332 | 0.0751 | 0.1266 | 0.0572 | 0.2668 | |
HLA-DRA | 0.1977 | *** | 0.2054 | *** | −0.0474 | 0.5220 | −0.1001 | 0.1811 | 0.0469 | 0.3406 | 0.0267 | 0.6049 | |
HLA-DPA1 | 0.1136 | ** | 0.1071 | ** | −0.0518 | 0.4836 | −0.1054 | 0.1592 | 0.0205 | 0.6767 | −0.0043 | 0.9341 | |
Th1 | STAT4 | 0.1423 | *** | 0.1485 | *** | 0.0918 | 0.2138 | 0.0214 | 0.7754 | −0.0223 | 0.6502 | −0.0431 | 0.4028 |
STAT1 | 0.3206 | *** | 0.3236 | *** | 0.0495 | 0.5036 | 0.0130 | 0.8626 | 0.0773 | 0.1159 | 0.0723 | 0.1599 | |
IFN-γ | 0.2338 | *** | 0.2368 | *** | 0.0282 | 0.7030 | −0.0218 | 0.7719 | 0.1110 | 0.0237 | 0.1006 | 0.0504 | |
Th2 | GATA3 | −0.3224 | *** | −0.3265 | *** | 0.0070 | 0.9250 | −0.0407 | 0.5879 | −0.1413 | 0.0039 | −0.1449 | 0.0047 |
STAT6 | −0.2108 | *** | −0.2203 | *** | −0.0115 | 0.8761 | −0.0058 | 0.9380 | 0.0082 | 0.8675 | 0.0083 | 0.8716 | |
STAT5A | −0.1037 | **6 | −0.1201 | ** | 0.0488 | 0.5094 | 0.0167 | 0.8244 | 0.0370 | 0.4519 | 0.0397 | 0.4409 | |
Tfh | BCL6 | −0.0880 | 0.0035 | −0.0987 | 0.0018 | 0.0279 | 0.7064 | 0.0100 | 0.8943 | 0.0353 | 0.4735 | −**2 | 0.9974 |
IL21 | 0.1499 | *** | 0.1506 | *** | −0.0226 | 0.7603 | −0.0743 | 0.3215 | 0.0307 | 0.5332 | 0.0137 | 0.7897 | |
Th7 | STAT3 | 0.0179 | 0.5523 | 0.0298 | 0.3472 | 0.0983 | 0.1831 | 0.0620 | 0.4083 | 0.0977 | 0.0467 | 0.0876 | 0.0887 |
IL17A | 0.1467 | *** | 0.1566 | *** | 0.0768 | 0.2987 | 0.0816 | 0.2759 | 0.2263 | *** | 0.1965 | ** | |
Treg | FOXP3 | 0.3249 | *** | 0.3291 | *** | 0.1025 | 0.1650 | 0.0592 | 0.4297 | 0.0589 | 0.2312 | 0.0611 | 0.2353 |
CCR8 | 0.3699 | *** | 0.3778 | *** | 0.1196 | 0.1050 | 0.0825 | 0.2710 | 0.1119 | 0.0226 | 0.1097 | 0.0328 | |
STAT5B | −0.2111 | *** | −0.2098 | *** | −0.0054 | 0.9901 | −0.0051 | 0.9457 | −0.0335 | 0.4964 | −0.0326 | 0.5270 | |
TGFβ | 0.5370 | *** | 0.5397 | *** | 0.4375 | *** | 0.4228 | *** | 0.1930 | ** | 0.1731 | ** | |
T cell exhaustion | CTLA4 | 0.2950 | *** | 0.3073 | *** | 0.0838 | 0.2570 | 0.0336 | 0.6543 | 0.0545 | 0.2676 | 0.0473 | 0.3581 |
LAG3 | 0.2435 | *** | 0.2369 | *** | 0.0022 | 0.9762 | −0.0412 | 0.5831 | 0.0309 | 0.5298 | 0.0131 | 0.7988 | |
GZMB | 0.3106 | *** | 0.3282 | *** | 0.0107 | 0.8855 | −0.0431 | 0.5652 | 0.1848 | ** | 0.1666 | 0.0011 |