Clinicopathological characteristics

Overall survival (n = 1402)

Rrgerreion-free survival (n = 3951)

N

Hazard ration

P-value

N

Hazard ration

P-value

ER

positive

2565

1.61 (1.24 - 2.09)

**

2565

1.61 (1.37 - 1.90)

***

negative

1214

1.10 (0.75 - 1.63)

0.6200

1214

1.16 (0.93 - 1.46)

0.1900

PR

postive

954

1.34 (0.35 - 5.09)

0.6700

954

1.36 (0.96 - 1.93)

0.0811

negative

1028

1.01 (0.40 - 2.55)

0.9800

1028

1.06 (0.79 - 1.42)

0.6969

HER2

postive

416

1.25 (0.62 - 2.50)

0.5300

416

0.94 (0.61 - 1.45)

0.7917

negative

1456

2.43 (0.94 - 6.28)

0.0580

1456

1.86 (1.42 - 2.44)

***

Intrinsic subtype

basal

879

1.65 (1.00 - 2.71)

0.0480

879

1.20 (0.94 - 1.55)

0.1483

luminal A

2504

1.72 (1.20 - 2.47)

0.0028

2504

1.89 (1.58 - 2.25)

***

luminal B

1425

1.30 (0.90 - 1.89)

0.1600

1425

1.28 (1.06 - 1.55)

0.0113

HER2+

335

0.57 (0.29 - 1.11)

0.0940

335

0.76 (0.52 - 1.12)

0.1593

lymph node status

postive

1459

1.13 (0.76 - 1.66)

0.5500

1459

1.67 (1.37 - 2.03)

***

negative

2259

2.00 (1.36 - 2.92)

**

2259

1.63 (1.37 - 1.93)

***

Grade

1

378

1.94 (0.76 - 4.94)

0.1600

378

1.50 (0.89 - 2.52)

0.1242

2

1077

1.75 (1.13 - 2.70)

0.0110

1077

1.60 (1.26 - 2.05)

**

3

1099

1.10 (0.80 - 1.53)

0.5600

1090

1.13 (0.91 - 1.40)

0.2809

TP53 status

mutated

232

0.53(0.24 - 1.19)

0.1200

232

0.84 (0.59 - 1.51)

0.7969

wild type

363

1.77 (0.91 - 3.45)

0.0870

363

1.40 (0.91 - 2.13)

0.1204