Independent Variable

Levels

−1

0

1

A = Polymer 1

CS concentration (w/v)

1.5

2

2.5

B = Polymer 2

PCL concentration (w/v)

0.1

0.2

0.3

C = Sonication Time (min)

10

15

20

D = Rate of Addition (min)

10

20

30

Dependent Variable

Constraint

EE = Encapsulation Efficiency (%)

Maximum