Polymer type

NPs preparation method

Loaded materials

Stabilizer

Cell line

Size (nm)

Zeta (mV)

References

Chitosan

Chemical reaction

-

-

Caco-2

(418 ± 31)-(531 ± 54)

(13.6 ± 0.8) - (29.4 ± 0.8)

[50]

Chitosan

Ionotropic gelation

Covalent conjugation with fluorescein- 5-isothiocyanate

-

A549 cells

195

35.5

[51]

Chitosan (Galactosylated)

Carbodiimide method

DNA

-

HepG2, HeLa

100 - 240

−5

[52]

Chitosan {Arg-Gly-Asp (RGD) peptide-labeled}

Ionic gelation

siRNA

-

SKOV3ip1, HeyA8, A2780, A2780ip2, MOECs

200

−40

[53]

Chitosan, PS, PEG-PLA

Multiple emulsion-solvent evaporation

-

Sodium Cholate

Caco-2, MTX-E12

(196 ± 20)-(290 ± 7)

(−23.9 ± 1.2) - (1.1 ± 1)

[7]

Chitosan-PEG

Ionic gelation

Caspase inhibitor pebptide

-

Mice

150

16

[54]

Gelatin

Desolvation

Anti CD3 mAb

-

HeLa

250 - 300

−20

[55]

Heparin

Coupling reaction through amide linkage

Paclitaxel, Folic acid

-

KB-3-1, Tu212

60

−16

[56]

Hyaluronic acid (Self-assembled)

Chemical conjugation through Carbodiimide method

-

PBS

SCC7, CV-1

237 - 424

-

[57]

Hyaluronic acid-ceramide

Self-assembly

Docetaxel

Pluronic P85

U87-MG, MCF-7, MCF-7/ADR

110 - 140

−20

[58]

Hydrophobically modified

glycol chitosan

Self-assembly

-

-

HeLa

359

22

[59]

Mesoporous silica

-

-

-

3T3-L1, HMSCs

108 - 115

(−4.9) - (19)

[60]

Methyl ether poly(ethylene glycol)-modified poly(beta-amino ester)

Solvent casting

Doxorubicin

-

B16F10

62

-

[61]

NAcHis-GC (self-assembled)

-

Paclitaxel

PBS

HeLa, A549

150 - 250

-

[62]

P(MDS-co-CES)

Self-assembly

DNA, Paclitaxel, Indomethacin, Pyrene

-

HEK293, HepG2, MDA-MB-231

(83 ± 1) - (180 ± 2)

(44 ± 2) - (84 ± 5)

[63]

PCL

Solvent displacement

Tamoxifen

Pluronic® F-68

MCF-7

250 - 300

6 - 25

[64] [65]

PCL

Emulsification diffusion

-

-

-

120 - 125

(−32) - (−60)

[66]