Major criteria

Minor criteria

Abrupt onset of characteristic rash

(papules and nodules)

Fever > 38 degrees Celsius

Biopsy proven dermal infiltration of neutrophilswithout vasculitis

Association with malignancy or

inflammatory syndrome

Excellent response to glucocorticoids

Elevated inflammatory markers on presentation (3 of 4)

・ ESR > 20 mm/h

・ Positive C-reactive protein

・ Leukocyte count > 10,000/ul

・ Over 70% neutrophils