Major criteria | Minor criteria |
Abrupt onset of characteristic rash (papules and nodules) | Fever > 38 degrees Celsius |
Biopsy proven dermal infiltration of neutrophilswithout vasculitis | Association with malignancy or inflammatory syndrome |
| Excellent response to glucocorticoids |
| Elevated inflammatory markers on presentation (3 of 4) ・ ESR > 20 mm/h ・ Positive C-reactive protein ・ Leukocyte count > 10,000/ul ・ Over 70% neutrophils |