Treatment | Dose (mg/kg) | Latency of nociceptive response (in seconds) | ||||
0 min | 30 min | 60 min | 90 min | 120 min | ||
Control | 0.1 mL/mouse | 7.20 ± 0.583 | 10.20 ± 0.583 | 11.80 ± 0.735 | 12.80 ± 0.860 | 15.00 ± 1.000 |
Standard (Morphine) | 5 | 13.80 ± 0.970 | 18.20 ± 1.562** | 21.40 ± 1.122* | 24.00 ± 1.095** | 27.40 ± 0.748** |
MEDM | 200 | 11.60 ± 0.812 | 16.00 ± 2.025 | 17.20 ± 1.241 | 20.40 ± 0.678 | 21.80 ± 0.970 |
MEDM | 400 | 12.20 ± 2.437 | 13.80 ± 1.020 | 18.60 ± 0.872 | 21.20 ± 1.200* | 24.80 ± 2.059* |
MEDM | 600 | 14.60 ± 0.927 | 18.80 ± 0.490 | 21.40 ± 2.159* | 23.60 ± 1.600** | 29.00 ± 0.447** |