Treatment

Dose (mg/kg)

Latency of nociceptive response (in seconds)

0 min

30 min

60 min

90 min

120 min

Control

0.1 mL/mouse

7.20

±

0.583

10.20

±

0.583

11.80

±

0.735

12.80

±

0.860

15.00

±

1.000

Standard (Morphine)

5

13.80

±

0.970

18.20

±

1.562**

21.40

±

1.122*

24.00

±

1.095**

27.40

±

0.748**

MEDM

200

11.60

±

0.812

16.00

±

2.025

17.20

±

1.241

20.40

±

0.678

21.80

±

0.970

MEDM

400

12.20

±

2.437

13.80

±

1.020

18.60

±

0.872

21.20

±

1.200*

24.80

±

2.059*

MEDM

600

14.60

±

0.927

18.80

±

0.490

21.40

±

2.159*

23.60

±

1.600**

29.00

±

0.447**