Treatment

Tail response time (Seconds)

0 min (T₀)

30 min (T₁)

60 min (T₂)

T₁ − T₀

T₂ − T₀

Distilled water 10 ml/kg

(Negative Control)

PBAE 100 mg/kg

PBAE 200 mg/kg

PBAE 400 mg/kg

Morphine 2 mL/kg

Positive Control)

1.14 ± 0.04

1.14 ± 0.04

1.11 ± 0.03

1.14 ± 0.02

1.18 ± 0.03

1.18 ± 0.04^a

1.49 ± 0.10*

1.13 ± 0.05^a,b

1.21 ± 0.05

1.31 ± 0.07^a,b

1.18 ± 0.02

1.68 ± 0.18*^,c

1.44 ± 0.10*^,c

1.84 ± 0.04*

2.00 ± 0.07*^,c

0.45 ± 0.04^d

0.36 ± 0.09*

0.02 ± 0.04*^,d

0.06 ± 0.03*

0.12 ± 0.04*^,d

0.04 ± 0.04

0.55 ± 0.18*^,e

0.33 ± 0.11*^,e

0.70 ± 0.04*^,e

0.81 ± 0.09*^,e