| Parameter | Basic model | Final model | ||
| Estimate (95% CI*) | % IIV (95% CI*) | Estimate (95% CI*) | % IIV (95% CI*) | |
| CL/F§ (L/h/70kg) | 14.3 (12.1 - 16.5) | 60 (14.1 - 55.5) |
|
|
| Ka (h−1) | 1.9 (1.0 - 4.0) | 120 (59.3 - 260.1) | 1.9 (1.0 - 4.4) | 120 (59.0 - 280.0) |
| V/F (L/70kg) | 597 (474.6 - 724.4) | 56 (9.4 - 48.8) | 580 (473.0 - 709.5) | 62 (27.3 - 48.7) |
| Alag (h) | 0.6 (0.4 - 0.8) | 18 (1.3 - 24.5) | 0.6 (0.3 - 0.8) | 23 (1.2 - 38.5) |
| Bioª | 1 | 26 (0.12 - 26.0) | - | - |
| σadd (%) | 41 (34.7 - 47.5) | - | 42 (37.2 - 45.7) | - |