Study

Patients (C/I)

Inclusion criteria

Intervention

Treatment time

Follow-up time

Outcomes/ assessments

Control group

Intervention group

Williams et al. (2002) [13]

30/29

Lymphedema ≥ 3 months after surgery, ≥10% volume difference between arms

Simple

lymphatic drainage (SLD)

MLD

12 weeks

12 weeks

Lymphedema volume; trunk swelling; dermis thickness; quality of life; symptoms/ altered sensations

McNeely et al. (2004) [11]

21/24

150 ml Volume difference between arms

Multi-layered compression

bandaging

MLD + multi-layered compression bandaging

6 months

60 months

Lymphedema volume

Gradalski et al. (2015) [10]

26/25

≥20% difference between limb volumes

Bandaging + physical exercises + deep diaphragmatic breathing

Bandaging + physical exercises + deep diaphragmatic breathing + MLD

26 weeks

12 months

Lymphedema volume

Tambour et al. (2018) [12]

35/38

Patients after breast cancer surgery; 20 mm circumference difference between arms, ll-lll stage

CDT+

MLD

CDT without MLD

4 weeks

7 months

Volume reduction in arm lymphoedema

Andersen et al. (2000) [8]

21/20

4 months after surgery; 20 mm circumference or 200 ml volume difference between arms

Standard

therapy

Standard

therapy + MLD

2 weeks

1, 3, 6, 9, 12 months

Volume reduction in arm with lymphoedema

Dayes et al. (2013) [9]

39/56

≥10% Volume difference between arms

Elastic compression garments

Elastic compression garments + MLD

4 weeks

6, 12, 24, 52 weeks

Volume reduction in arm with lymphoedema; quality of life; arm function assessed