Genes found in the healthy ESR pathway

Gene variants involved in the healthy ESR pathway

Estradiol-17 beta (E2)

Matrix metalloproteinase (MMP)

MMP2, MMP9

Heparin-binding EGF-like growth factor (HBEGF)

Gamma-aminobutyric acid (GABA)

Beta-Endorphin (╬▓End)

Adenylate Cyclase (AC)

ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9

Epidermal growth factor receptor (EGFR)

Gamma-aminobutyric acid B receptor (GABAB)

GABBR

GIRK

KCNJ3, KCNJ5, KCNJ6, KCNJ9

Opioid receptor µ (OPRM1)

Membrane estrogen receptor (mER)

Metabotropic glutamate receptors (mGluR1a)

GRM1

Estrogen receptor (ER)

NR3A1, NR3A2

Proto-oncogene, non-receptor tyrosine kinase (c-Src)

Src

Tyrosine-protein kinase (Shc)

Shc1, Shc2, Shc3, Shc4

Cyclic adenosine monophosphate (cAMP)

Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)

PIK3C, PIK3R

Guanine nucleotide-binding protein G(i) subunit alpha (Gi/o)

GNAI, GNAO

Novel protein kinase C delta type (PKC delta)

PRKCD

Guanine Nucleotide-Binding Protein Alpha-Q (Gq)

GNAQ

Adenylate Cyclase-Stimulating G Alpha Protein (Gs)

GNAS

Protein kinase cAMP-activated catalytic subunit alpha (PKA)

Growth factor receptor bound protein 2 (Grb2)

Rac serine/threonine-protein kinase (Akt)

Phospholipase C (PLC)

PLGB

GTPaseHras (Ras)

HRAS, KRAS, NRAS

G protein-coupled estrogen receptor (GPER)

GPR30

Son of Sevenless (SOS)

Diaclyglycerol (DAG)

Inositol 1,4,5-trisphosphate receptor (IP3R)

ITPR1, ITPR2, ITPR3

Calmodulin (CAM)

CALM

Nitric oxide synthase 3 (eNOS)

NOS3