| Genes found in the healthy ESR pathway | Gene variants involved in the healthy ESR pathway |
| Estradiol-17 beta (E2) | |
| Matrix metalloproteinase (MMP) | MMP2, MMP9 |
| Heparin-binding EGF-like growth factor (HBEGF) | |
| Gamma-aminobutyric acid (GABA) | |
| Beta-Endorphin (βEnd) | |
| Adenylate Cyclase (AC) | ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9 |
| Epidermal growth factor receptor (EGFR) | |
| Gamma-aminobutyric acid B receptor (GABAB) | GABBR |
| GIRK | KCNJ3, KCNJ5, KCNJ6, KCNJ9 |
| Opioid receptor µ (OPRM1) | |
| Membrane estrogen receptor (mER) | |
| Metabotropic glutamate receptors (mGluR1a) | GRM1 |
| Estrogen receptor (ER) | NR3A1, NR3A2 |
| Proto-oncogene, non-receptor tyrosine kinase (c-Src) | Src |
| Tyrosine-protein kinase (Shc) | Shc1, Shc2, Shc3, Shc4 |
| Cyclic adenosine monophosphate (cAMP) | |
| Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) | PIK3C, PIK3R |
| Guanine nucleotide-binding protein G(i) subunit alpha (Gi/o) | GNAI, GNAO |
| Novel protein kinase C delta type (PKC delta) | PRKCD |
| Guanine Nucleotide-Binding Protein Alpha-Q (Gq) | GNAQ |
| Adenylate Cyclase-Stimulating G Alpha Protein (Gs) | GNAS |
| Protein kinase cAMP-activated catalytic subunit alpha (PKA) | |
| Growth factor receptor bound protein 2 (Grb2) | |
| Rac serine/threonine-protein kinase (Akt) | |
| Phospholipase C (PLC) | PLGB |
| GTPaseHras (Ras) | HRAS, KRAS, NRAS |
| G protein-coupled estrogen receptor (GPER) | GPR30 |
| Son of Sevenless (SOS) | |
| Diaclyglycerol (DAG) | |
| Inositol 1,4,5-trisphosphate receptor (IP3R) | ITPR1, ITPR2, ITPR3 |
| Calmodulin (CAM) | CALM |
| Nitric oxide synthase 3 (eNOS) | NOS3 |