Variable

Standard CPH model

Cox model with continuous time varying effects (Model A)

Cox model with piecewise time varying effects (Modified model B)

β ^

Hazard Ratio

95% Confidence Interval

β ^

Hazard Ratio

95% Confidence Interval

β ^

Hazard Ratio

95% Confidence Interval

Race-black

0.6001

1.816

1.261

2.615

0.5168

1.677

1.162

2.420

0.5179

1.678

1.163

2.423

Race-other

−0.4758

0.622

0.336

1.152

−0.6768

0.508

0.272

0.950

-0.6728

0.510

0.273

0.954

Lymphnode-positive

0.7231

2.059

1.463

2.898

0.7591

2.136

1.521

3.000

0.7599

2.138

1.522

3.004

Lymphnode-unknown

0.7998

2.218

1.504

3.271

0.8205

2.272

1.525

3.384

0.8195

2.269

1.523

3.381

Stage II

0.5933

1.808

1.248

2.620

0.2789

1.322

0.895

1.951

0.2783

1.321

0.894

1.951

Stage III

0.8522

2.339

1.481

3.692

0.5741

1.776

1.099

2.870

0.5710

1.770

1.095

2.862

Stage IV

1.8908

6.575

3.709

11.654

1.8176

6.157

3.354

11.303

1.8209

6.177

3.363

11.348

Tumor size

0.0069

1.007

1.002

1.012

FPsize

0.6205

1.860

1.489

2.324

0.6176

1.854

1.484

2.317

Age

0.0381

1.039

1.029

1.048

FPage

0.0424

1.043

1.025

1.062

0.0422

1.043

1.024

1.062

FPage × time

0.0039

1.004

1.001

1.007

0.0038

1.004

1.001

1.007

PRA-positive

0.4303

1.534

1.211

1.943

0.0543

1.056

0.763

1.461

PRA × β P R A e k t

1.3726

3.946

2.336

6.666

PRA × β P R A 1 ( t )

1.3152

3.725

2.034

6.824

PRA × β P R A 2 ( t )

0.7182

2.051

1.292

3.254