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Statistic

CD4+ T cell response frequency (%)

CD8+ T cell response frequency (%)

5+

4+

3+

2+

1+

5+

4+

3+

2+

1+

Pre-vac

Mean ± SD

0.000 ± 0.000

0.000 ± 0.000

0.002 ± 0.004

0.006 ± 0.009

0.038 ± 0.055

0.002 ± 0.004

0.000 ± 0.000

0.008 ± 0.018

0.006 ± 0.013

0.016 ± 0.036

Median (min - max)

0.00 (0.00 - 0.00)

0.00 (0.00 - 0.00)

0.00 (0.00 - 0.01)

0.00 (0.00 - 0.02)

0.00 (0.00 - 0.12)

0.00 (0.00 - 0.01)

0.00 (0.00 - 0.00)

0.00 (0.00 - 0.04)

0.00 (0.00 - 0.03)

0.00 (0.00 - 0.08)

1 month

Mean ± SD

0.022 ± 0.049

0.092 ± 0.195

0.336 ± 0.514

1.120 ± 1.180

3.548 ± 2.222

0.090 ± 0.084

0.932 ± 0.773

3.004 ± 2.905

14.786 ± 9.650

21.334 ± 8.978

Median (min - max)

0.00 (0.00 - 0.11)

0.01 (0.00 - 0.44)

0.12 (0.03 - 1.25)

0.70 (0.17 - 3.16)

2.95 (1.13 - 7.13)

0.06 (0.01 - 0.18)

0.79 (0.18 - 1.87)

2.00 (0.57 - 7.61)

12.83 (1.43 - 27.26)

21.08 (9.90 - 34.83)

p-value

0.374

0.35

0.221

0.103

0.026

0.082

0.054

0.083

0.027

0.006

3 months

Mean ± SD

0.016 ± 0.036

0.072 ± 0.144

0.240 ± 0.353

0.730 ± 0.600

2.552 ± 1.319

0.094 ± 0.141

1.394 ± 1.416

3.146 ± 2.856

14.652 ± 11.128

19.236 ± 8.326

Median (min - max)

0.00 (0.00 - 0.08)

0.01 (0.00 - 0.33)

0.08 (0.06 - 0.87)

0.45 (0.42 - 1.80)

1.88 (1.71 - 4.83)

0.01 (0.00 - 0.33)

1.20 (0.10 - 3.78)

2.56 (0.38 - 7.88)

16.42 (1.01 - 29.77)

21.73 (7.75 - 29.15)

p-value

0.374

0.328

0.207

0.055

0.014

0.217

0.093

0.07

0.042

0.007

6 months

Mean ± SD

0.012 ± 0.016

0.066 ± 0.099

0.216 ± 0.237

0.758 ± 0.480

2.682 ± 1.379

0.054 ± 0.067

0.998 ± 0.863

2.124 ± 1.302

12.414 ± 9.226

17.184 ± 7.180

Median (min - max)

0.01 (0.00 - 0.04)

0.04 (0.00 - 0.24)

0.21 (0.00 - 0.60)

1.05 (0.22 - 1.18)

2.6 (1.34 - 4.61)

0.01 (0.01 - 0.16)

0.84 (0.09 - 2.28)

2.73 (0.22 - 3.23)

12.54 (0.87 - 22.44)

18.85 (5.30 - 23.95)

p-value

0.178

0.21

0.114

0.024

0.011

0.137

0.061

0.022

0.04

0.006

12 months

Mean ± SD

0.006 ± 0.009

0.032 ± 0.044

0.180 ± 0.170

0.714 ± 0.752

2.074 ± 2.313

0.042 ± 0.032

0.546 ± 0.515

1.130 ± 0.881

10.476 ± 9.062

13.818 ± 11.298

Median (min - max)

0.00 (0.00 - 0.02)

0.00 (0.00 - 0.09)

0.14 (0.01 - 0.46)

0.45 (0.17 - 2.01)

0.75 (0.36 - 5.79)

0.05 (0.00 - 0.08)

0.45 (0.07 - 1.37)

1.08 (0.06 - 2.31)

15.51 (0.07 - 18.11)

13.26 (0.08 - 26.08)

p-value

0.208

0.182

0.082

0.103

0.116

0.037

0.077

0.047

0.061

0.052