Visit | Statistic | CD4+ T cell response frequency (%) | CD8+ T cell response frequency (%) | ||||||||
5+ | 4+ | 3+ | 2+ | 1+ | 5+ | 4+ | 3+ | 2+ | 1+ | ||
Pre-vac | Mean ± SD | 0.000 ± 0.000 | 0.000 ± 0.000 | 0.002 ± 0.004 | 0.006 ± 0.009 | 0.038 ± 0.055 | 0.002 ± 0.004 | 0.000 ± 0.000 | 0.008 ± 0.018 | 0.006 ± 0.013 | 0.016 ± 0.036 |
Median (min - max) | 0.00 (0.00 - 0.00) | 0.00 (0.00 - 0.00) | 0.00 (0.00 - 0.01) | 0.00 (0.00 - 0.02) | 0.00 (0.00 - 0.12) | 0.00 (0.00 - 0.01) | 0.00 (0.00 - 0.00) | 0.00 (0.00 - 0.04) | 0.00 (0.00 - 0.03) | 0.00 (0.00 - 0.08) | |
1 month | Mean ± SD | 0.022 ± 0.049 | 0.092 ± 0.195 | 0.336 ± 0.514 | 1.120 ± 1.180 | 3.548 ± 2.222 | 0.090 ± 0.084 | 0.932 ± 0.773 | 3.004 ± 2.905 | 14.786 ± 9.650 | 21.334 ± 8.978 |
Median (min - max) | 0.00 (0.00 - 0.11) | 0.01 (0.00 - 0.44) | 0.12 (0.03 - 1.25) | 0.70 (0.17 - 3.16) | 2.95 (1.13 - 7.13) | 0.06 (0.01 - 0.18) | 0.79 (0.18 - 1.87) | 2.00 (0.57 - 7.61) | 12.83 (1.43 - 27.26) | 21.08 (9.90 - 34.83) | |
p-value | 0.374 | 0.35 | 0.221 | 0.103 | 0.026 | 0.082 | 0.054 | 0.083 | 0.027 | 0.006 | |
3 months | Mean ± SD | 0.016 ± 0.036 | 0.072 ± 0.144 | 0.240 ± 0.353 | 0.730 ± 0.600 | 2.552 ± 1.319 | 0.094 ± 0.141 | 1.394 ± 1.416 | 3.146 ± 2.856 | 14.652 ± 11.128 | 19.236 ± 8.326 |
Median (min - max) | 0.00 (0.00 - 0.08) | 0.01 (0.00 - 0.33) | 0.08 (0.06 - 0.87) | 0.45 (0.42 - 1.80) | 1.88 (1.71 - 4.83) | 0.01 (0.00 - 0.33) | 1.20 (0.10 - 3.78) | 2.56 (0.38 - 7.88) | 16.42 (1.01 - 29.77) | 21.73 (7.75 - 29.15) | |
p-value | 0.374 | 0.328 | 0.207 | 0.055 | 0.014 | 0.217 | 0.093 | 0.07 | 0.042 | 0.007 | |
6 months | Mean ± SD | 0.012 ± 0.016 | 0.066 ± 0.099 | 0.216 ± 0.237 | 0.758 ± 0.480 | 2.682 ± 1.379 | 0.054 ± 0.067 | 0.998 ± 0.863 | 2.124 ± 1.302 | 12.414 ± 9.226 | 17.184 ± 7.180 |
Median (min - max) | 0.01 (0.00 - 0.04) | 0.04 (0.00 - 0.24) | 0.21 (0.00 - 0.60) | 1.05 (0.22 - 1.18) | 2.6 (1.34 - 4.61) | 0.01 (0.01 - 0.16) | 0.84 (0.09 - 2.28) | 2.73 (0.22 - 3.23) | 12.54 (0.87 - 22.44) | 18.85 (5.30 - 23.95) | |
p-value | 0.178 | 0.21 | 0.114 | 0.024 | 0.011 | 0.137 | 0.061 | 0.022 | 0.04 | 0.006 | |
12 months | Mean ± SD | 0.006 ± 0.009 | 0.032 ± 0.044 | 0.180 ± 0.170 | 0.714 ± 0.752 | 2.074 ± 2.313 | 0.042 ± 0.032 | 0.546 ± 0.515 | 1.130 ± 0.881 | 10.476 ± 9.062 | 13.818 ± 11.298 |
Median (min - max) | 0.00 (0.00 - 0.02) | 0.00 (0.00 - 0.09) | 0.14 (0.01 - 0.46) | 0.45 (0.17 - 2.01) | 0.75 (0.36 - 5.79) | 0.05 (0.00 - 0.08) | 0.45 (0.07 - 1.37) | 1.08 (0.06 - 2.31) | 15.51 (0.07 - 18.11) | 13.26 (0.08 - 26.08) | |
p-value | 0.208 | 0.182 | 0.082 | 0.103 | 0.116 | 0.037 | 0.077 | 0.047 | 0.061 | 0.052 |