Combinations | MIC | FICs | FIC index | Interaction | ||
FLC (µg/ml) | Comp. (mM) | FLC | Comp. | |||
A. Planktonic Growth (MIC100) | ||||||
FLC alone | ˃128 | 0 | 1 | 0 | 1 | NI |
Ocimene + FLC | 4 | 22 | 0.031 | 0.124 | 0.155 | synergistic |
Ocimene alone | 0 | 176.4 | 0 | 1 | 1 | NI |
Cinnamaldehyde + FLC | 4 | 0.15 | 0.031 | 0.241 | 0.273 | synergistic |
Cinnamaldehyde | 0 | 0.62 | 0 | 1 | 1 | NI |
Farnesene + FLC | 8 | 12.5 | 0.062 | 0.125 | 0.187 | synergistic |
Farnesene alone | 0 | 100 | 0 | 1 | 1 | NI |
Curcumin + FLC | 8 | 2.5 | 0.062 | 0.125 | 0.187 | synergistic |
Curcumin alone | 0 | 20 | 0 | 1 | 1 | NI |
Camphene + FLC | 8 | 4 | 0.064 | 0.25 | 0.289 | synergistic |
Camphene alone | 0 | 16 | 0 | 1 | 1 | NI |
B. Developing Biofilm (MIC90) | ||||||
FLC alone | ˃256 | 0 | 1 | 0 | 1 | NI |
Cinnamaldehyde + FLC | 8 | 0.152 | 0.031 | 0.030 | 0.061 | Synergistic |
Cinnamaldehyde | 0 | 5 | 0 | 1 | 1 | NI |
Farnesene + FLC | 8 | 18.7 | 0.031 | 0.062 | 0.093 | Synergistic |
Farnesene | 0 | 300 | 0 | 1 | 1 |
|
MIC80 | ||||||
Ocimene + FLC | 8 | 5.5 | 0.031 | 0.031 | 0.062 | Synergistic |
Ocimene | 0 | 176.8 | 0 | 1 | 1 | NI |
Camphene + FLC | 8 | 1.5 | 0.031 | 0.125 | 0.156 | Synergistic |
Camphene | 0 | 12 | 0 | 1 | 1 |
|
MIC70 | ||||||
Curcumin + FLC | 8 | 1.85 | 0.031 | 0.030 | 0.062 | Synergistic |
Curcumin | 0 | 60 | 0 | 1 | 1 | NI |
C. Mature Biofilm (MIC 90) | ||||||
FLC alone | ˃256 | 0 | 1 | 0 | 1 | NI |
Cinnamaldehyde + FLC | 8 | 0.152 | 0.031 | 0.030 | 0.061 | Synergistic |
Cinnamaldehyde | 0 | 5 | 0 | 1 | 1 | NI |
MIC80 | ||||||
FLC alone | ˃256 | 0 | 1 | 0 | 1 | NI |
Ocimene + FLC | 8 | 5.5 | 0.031 | 0.015 | 0.046 | Synergistic |
Ocimene alone | 0 | 352 | 0 | 1 | 1 | NI |
MIC50 | ||||||
FLC alone | 256 | 0 | 1 | 0 | 1 | NI |
Farnesene + FLC | 8 | 9.35 | 0.031 | 0.249 | 0.280 | Synergistic |
Farnesene | 0 | 37.5 | 0 | 1 | 1 |
|
Camphene + FLC | 8 | 0.75 | 0.031 | 0.031 | 0.062 | Synergistic |
Camphene | 0 | 24 | 0 | 1 | 1 | NI |