| Organism | Type of aptamer | Target | Aptamer therapeutic effect |
| HBV | DNA | Core protein | -Prevent the assembly of the nucleocapsid -function by suppressing HBV replication |
| HCV | DNA | Envelope Protein | -Inhibition of virus binding to host cells |
| Influenza A virus | DNA | Hemagglutinin protein | -Blocking the binding of virus to target cell receptors -prevention of the virus invasion into the host cells |
| Ebola Virus | RNA | VP35 | -Disrupt the eVP35−NP interaction |
| HIV-1 | RNA | gag protein | -Inhibit HIV-1 replication |
| HSV-1 | RNA | gD protein | -Blocking the gD functions |
| Vaccinia virus | DNA | Hemagglutinin protein | -Recognize proteins expressed on the surface of VV-infected cells |
| Influenza B Virus | RNA | Hemagglutinin protein | -Inhibited HA-mediated membrane fusion |
| SCV | RNA | nsP10 | -Inhibit double-stranded DNA unwinding activity of the helicase |
| Rabies virus | DNA | Blocking the interaction between rabies virus and permissive host cell receptors | -Reduced viral replication in an in vitro infection model |