*Treatment Options

Day 0

Control

Day 5

Control

Day 10

Control

Day 15

Control

Day 20

Control

Day 25

Control

A1

334.71 ± 0.77

247.94 ± 0.23

253.57 ± 0.34

187.83 ± 0.44

192.10 ± 0.22

142.30 ± 0.44

145.53 ± 0.65

107.80 ± 0.33

108.63 ± 0.30

111.69 ± 0.16

101.00 ± 0.56

111.00 ± 0.23

B

340.35 ± 0.43

247.94 ± 0.50

257.84 ± 0.65

187.83 ± 0.54

195.33 ± 0.88

142.30 ± 0.88

147.98 ± 0.65

107.80 ± 0.67

135.15 ± 0.16

111.69 ± 0.30

132.45 ± 0.76

111.00 ± 0.60

E

323.44 ± 0.76

247.94 ± 0.43

245.03 ± 0.15

187.83 ± 0.30

185.63 ± 0.40

142.30 ± 0.71

140.63 ± 0.49

107.80 ± 0.81

130.56 ± 0.30

111.69 ± 0.68

113.15 ± 0.23

111.00 ± 0.11

K

353.87 ± 0.53

247.94 ± 0.94

268.09 ± 0.68

187.83 ± 0.87

203.10 ± 0.30

142.30 ± 0.42

153.86 ± 0.86

107.80 ± 0.17

114.24 ± 0.14

111.69 ± 0.60

107.33 ± 0.74

111.00 ± 0.40

A1 + B

386.56 ± 0.19

247.94 ± 0.18

292.85 ± 0.18

187.83 ± 0.18

221.85 ± 0.58

142.30 ± 0.19

168.07 ± 0.94

107.80 ± 0.77

125.46 ± 0.28

111.69 ± 0.21

122.27 ± 0.90

111.00 ± 0.70

A1 + E

351.62 ± 0.65

247.94 ± 0.49

266.38 ± 0.18

187.83 ± 0.76

201.80 ± 0.27

142.30 ± 0.20

152.88 ± 0.17

107.80 ± 0.39

121.89 ± 0.60

111.69 ± 0.15

118.20 ± 0.16

111.00 ± 0.49

A1 + K

436.14 ± 0.89

247.94 ± 0.43

330.41 ± 0.87

187.83 ± 0.76

250.31 ± 0.65

142.30 ± 0.42

189.63 ± 0.87

107.80 ± 0.43

113.73 ± 0.65

111.69 ± 0.71

111.00 ± 0.21

111.00 ± 0.65

B + E

375.29 ± 0.65

247.94 ± 0.42

284.31 ± 0.76

187.83 ± 0.67

215.38 ± 0.78

142.30 ± 0.45

163.17 ± 0.78

107.80 ± 0.23

134.64 ± 0.89

111.69 ± 0.83

115.75 ± 0.42

111.00 ± 0.76

B + K

451.92 ± 0.56

247.74 ± 0.91

342.36 ± 0.67

187.83 ± 0.91

259.37 ± 0.78

142.30 ± 0.34

196.49 ± 0.78

107.80 ± 0.12

120.36 ± 0.43

111.69 ± 0.78

111.90 ± 0.67

111.00 ± 0.12

E + K

396.70 ± 0.13

247.94 ± 0.12

300.53 ± 0.39

187.83 ± 0.83

227.67 ± 0.22

142.30 ± 0.39

172.48 ± 0.39

107.80 ± 0.29

129.54 ± 0.19

111.69 ± 0.13

116.00 ± 0.22

111.00 ± 0.32

A1 + E + K

482.35 ± 0.82

247.94 ± 0.24

365.42 ± 0.64

187.83 ± 0.87

276.83 ± 0.76

142.30 ± 0.24

209.72 ± 0.27

107.80 ± 0.47

124.44 ± 0.45

111.69 ± 0.67

122.13 ± 0.32

111.00 ± 0.19

B + E + K

447.41 ± 0.14

247.94 ± 0.47

338.95 ± 0.59

187.83 ± 0.79

256.78 ± 0.65

142.30 ± 0.47

194.53 ± 0.34

107.80 ± 0.99

132.09 ± 0.23

111.69 ± 0.11

114.71 ± 0.14

111.00 ± 0.12

A1 + B + E

414.73 ± 0.17

247.94 ± 0.49

314.19 ± 0.19

187.83 ± 0.66

238.02 ± 0.39

142.30 ± 0.43

180.32 ± 0.23

107.80 ± 0.87

127.50 ± 0.54

111.69 ± 0.12

125.30 ± 0.55

111.00 ± 0.65

A1 + B + K

458.68 ± 0.78

247.94 ± 0.62

347.49 ± 0.61

187.83 ± 0.78

268.25 ± 0.56

142.30 ± 0.78

199.43 ± 0.66

107.80 ± 0.47

133.11 ± 0.56

111.69 ± 0.62

114.00 ± 0.61

111.00 ± 0.55

A1 + B + E + K

499.25 ± 0.73

247.94 ± 0.73

239.91 ± 0.73

187.83 ± 0.32

283.53 ± 0.51

142.30 ± 0.48

217.07 ± 0.54

107.80 ± 0.17

130.05 ± 0.48

111.69 ± 0.65

74.12 ± 0.54

111.00 ± 0.29

A2

316.68 ± 0.76

247.94 ± 0.66

239.73 ± 0.32

187.83 ± 0.82

181.75 ± 0.87

142.30 ± 0.66

137.69 ± 0.53

107.80 ± 0.64

121.89 ± 0.87

111.69 ± 0.64

62.30 ± 0.53

111.00 ± 0.18

P

303.16 ± 0.53

247.94 ± 0.74

229.67 ± 0.83

187.83 ± 0.53

173.99 ± 0.25

142.30 ± 0.83

131.81 ± 0.38

107.80 ± 0.53

230.93 ± 0.22

111.69 ± 0.66

120.00 ± 0.46

111.00 ± 0.53

A2 + P

343.73 ± 0.46

247.94 ± 0.78

260.40 ± 0.56

187.83 ± 0.42

197.27 ± 0.54

142.30 ± 0.42

149.40 ± 0.93

107.80 ± 0.39

135.15 ± 0.93

111.69 ± 0.48

134.70 ± 0.42

111.00 ± 0.39