*Treatment Options

Day 0

Control

Day 5

Control

Day 10

Control

Day 15

Control

Day 20

Control

Day 25

Control

A1

119.28 ± 0.03

100.74 ± 0.44

98.01 ± 0.23

99.22 ± 0.87

92.37 ± 0.36

130.97 ± 0.65

70.77 ± 0.82

172.88 ± 0.50

65.42 ± 0.76

128.20 ± 0.30

47.45 ± 0.47

127.00 ± 0.56

B

121.90 ± 0.54

100.74 ± 0.60

99.66 ± 0.32

99.22 ± 0.55

92.55 ± 0.70

130.97 ± 0.54

73.65 ± 0.45

172.88 ± 0.44

69.21 ± 0.19

128.20 ± 0.65

52.27 ± 0.63

127.00 ± 0.74

E

117.76 ± 0.56

100.74 ± 0.98

94.71 ± 0.12

99.22 ± 0.40

95.02 ± 0.50

130.97 ± 0.32

75.02 ± 0.12

172.88 ± 0.18

67.83 ± 0.67

128.20 ± 0.28

53.50 ± 0.54

127.00 ± 0.12

K

129.92 ± 0.92

100.74 ± 0.74

103.62 ± 0.62

99.22 ± 0.22

93.78 ± 0.33

130.97 ± 0.30

80.55 ± 0.80

172.88 ± 0.88

68.32 ± 0.63

128.20 ± 0.87

58.00 ± 0.76

127.00 ± 0.39

A1 + B

113.16 ± 0.17

100.74 ± 0.18

102.90 ± 0.32

99.22 ± 0.17

93.83 ± 0.38

130.97 ± 0.65

79.29 ± 0.45

172.88 ± 0.17

66.67 ± 0.45

128.20 ± 0.18

42.22 ± 0.37

127.00 ± 0.15

A1 + E

133.84 ± 0.16

100.74 ± 0.40

102.96 ± 0.45

99.22 ± 0.55

93.90 ± 0.48

130.97 ± 0.34

79.40 ± 0.66

172.88 ± 0.48

66.20 ± 0.89

128.20 ± 0.13

45.90 ± 0.30

127.00 ± 0.30

A1 + K

129.34 ± 0.71

100.74 ± 0.65

116.10 ± 0.91

99.22 ± 0.18

93.25 ± 0.56

130.97 ± 0.21

72.29 ± 0.16

172.88 ± 0.65

67.03 ± 0.67

128.20 ± 0.42

47.00 ± 0.36

127.00 ± 0.71

B + E

121.44 ± 0.78

100.74 ± 0.67

109.89 ± 0.77

99.22 ± 0.34

94.05 ± 0.50

130.97 ± 0.76

71.47 ± 0.50

172.88 ± 0.76

52.74 ± 0.42

128.20 ± 0.23

53.70 ± 0.24

127.00 ± 0.50

B + K

125.08 ± 0.78

100.74 ± 0.83

120.30 ± 0.39

99.22 ± 0.56

95.08 ± 0.31

130.97 ± 0.42

79.61 ± 0.24

172.88 ± 0.56

66.69 ± 0.45

128.20 ± 0.12

46.44 ± 0.34

127.00 ± 0.31

E + K

124.46 ± 0.42

100.74 ± 0.55

116.16 ± 0.23

99.22 ± 0.18

93.33 ± 0.33

130.97 ± 0.77

72.40 ± 0.45

172.88 ± 0.29

62.16 ± 0.30

128.20 ± 0.29

54.20 ± 0.19

127.00 ± 0.30

A1 + E + K

131.76 ± 0.31

100.74 ± 0.75

128.40 ± 0.82

99.22 ± 0.22

89.49 ± 0.94

130.97 ± 0.79

63.72 ± 0.27

172.88 ± 0.86

55.32 ± 0.53

128.20 ± 0.28

62.13 ± 0.32

127.00 ± 0.27

B + E + K

132.09 ± 0.23

100.74 ± 0.47

131.01 ± 0.31

99.22 ± 0.45

72.93 ± 0.60

130.97 ± 0.79

60.27 ± 0.72

172.88 ± 0.27

51.32 ± 0.31

128.20 ± 0.39

54.30 ± 0.43

127.00 ± 0.72

A1 + B + E

115.00 ± 0.27

100.74 ± 0.19

121.44 ± 0.45

99.22 ± 0.23

86.30 ± 0.45

130.97 ± 0.67

61.6 ± 0.46

172.88 ± 0.29

59.31 ± 0.97

128.20 ± 0.28

47.37 ± 0.74

127.00 ± 0.72

A1 + B + K

120.06 ± 0.66

100.74 ± 0.56

105.82 ± 0.47

99.22 ± 0.62

89.68 ± 0.66

130.97 ± 0.43

64.38 ± 0.62

172.88 ± 0.25

63.38 ± 0.47

128.20 ± 0.78

45.00 ± 0.55

127.00 ± 0.56

A1 + B + E + K

117.30 ± 0.19

100.74 ± 0.13

92.73 ± 0.54

99.22 ± 0.54

86.19 ± 0.54

130.97 ± 0.73

62.97 ± 0.32

172.88 ± 0.73

54.72 ± 0.29

128.20 ± 0.13

47.75 ± 0.66

127.00 ± 0.54

A2

109.94 ± 082

100.74 ± 0.43

92.73 ± 0.23

99.22 ± 0.34

82.40 ± 0.64

130.97 ± 0.76

61.57 ± 0.44

172.88 ± 0.66

53.28 ± 0.53

128.20 ± 0.82

56.28 ± 0.34

127.00 ± 0.82

P

123.93 ± 0.64

100.74 ± 0.37

88.77 ± 0.43

99.22 ± 0.44

97.18 ± 0.13

130.97 ± 0.98

74.67 ± 0.73

172.88 ± 0.83

64.17 ± 0.38

128.20 ± 0.98

58.25 ± 0.28

127.00 ± 0.32

A2 + P

121.90 ± 0.33

100.74 ± 0.36

100.65 ± 0.42

99.22 ± 0.34

92.86 ± 0.24

130.97 ± 0.83

75.37 ± 0.24

172.88 ± 0.83

63.49 ± 0.42

128.20 ± 0.39

47.24 ± 0.42

127.00 ± 0.42