*Treatment Options

Day 0

Control

Day 5

Control

Day 10

Control

Day 15

Control

Day 20

Control

Day 25

Control

A1

6.87 ± 0.12

6.98 ± 0.54

5.76 ± 0.77

6.95 ± 0.44

4.95 ± 0.35

6.67 ± 0.65

4.26 ± 0.64

6.41 ± 0.14

3.66 ± 0.80

6.15 ± 0.22

3.58 ± 0.55

6.40 ± 0.44

B

6.64 ± 0.68

6.98 ± 0.89

5.63 ± 0.30

6.95 ± 0.67

4.84 ± 0.84

6.67 ± 0.88

4.16 ± 0.76

6.41 ± 0.12

3.58 ± 0.32

6.15 ± 0.50

3.52 ± 0.33

6.11 ± 0.65

E

6.79 ± 0.65

6.98 ± 0.75

5.58 ± 0.64

6.95 ± 0.80

4.88 ± 0.45

6.67 ± 0.29

4.20 ± 0.43

6.41 ± 0.39

3.61 ± 0.38

6.15 ± 0.16

3.56 ± 0.57

6.11 ± 0.16

K

6.66 ± 0.67

6.98 ± 0.98

5.72 ± 0.52

6.95 ± 0.34

4.92 ± 0.92

6.67 ± 0.65

4.23 ± 0.43

6.41 ± 0.42

3.64 ± 0.65

6.15 ± 0.22

3.60 ± 0.89

6.11 ± 0.43

A1 + B

6.59 ± 0.25

6.98 ± 0.18

5.59 ± 0.62

6.95 ± 0.59

4.81 ± 0.51

6.67 ± 0.31

4.13 ± 0.43

6.41 ± 0.12

3.56 ± 0.49

6.15 ± 0.30

3.45 ± 0.31

6.11 ± 0.23

A1 + E

6.74 ± 0.19

6.95 ± 0.19

5.47 ± 0.18

6.95 ± 0.60

4.70 ± 0.66

6.67 ± 0.39

4.05 ± 0.67

6.41 ± 0.64

3.48 ± 0.23

6.15 ± 0.70

3.48 ± 0.45

6.11 ± 0.46

A1 + K

6.87 ± 0.87

6.98 ± 0.17

5.54 ± 0.43

6.95 ± 0.22

4.76 ± 0.36

6.67 ± 0.43

4.10 ± 0.42

6.41 ± 0.67

3.52 ± 0.36

6.15 ± 0.56

3.48 ± 0.42

6.11 ± 0.43

B + E

6.64 ± 0.34

6.98 ± 0.23

5.49 ± 0.24

6.95 ± 0.23

4.72 ± 0.77

6.67 ± 0.24

4.06 ± 0.16

6.41 ± 0.24

3.49 ± 0.50

6.15 ± 0.34

3.45 ± 0.16

6.11 ± 0.45

B + K

6.89 ± 0.91

6.00 ± 0.50

5.55 ± 0.67

6.95 ± 0.43

4.77 ± 0.39

6.67 ± 0.33

4.10 ± 0.31

6.41 ± 0.50

3.53 ± 0.76

6.15 ± 0.16

3.50 ± 0.83

6.11 ± 0.24

E + K

6.46 ± 0.33

6.98 ± 0.56

5.46 ± 0.27

6.95 ± 0.30

4.70 ± 0.30

6.67 ± 0.19

4.04 ± 0.16

6.41 ± 0.29

3.47 ± 0.40

6.15 ± 0.12

3.41 ± 0.19

6.11 ± 0.39

A1 + E + K

6.88 ± 0.29

6.98 ± 0.39

5.47 ± 0.30

6.95 ± 0.33

4.70 ± 0.50

6.67 ± 0.49

4.05 ± 0.18

6.41 ± 0.20

3.48 ± 0.18

6.15 ± 0.15

3.44 ± 0.39

6.11 ± 0.29

B + E + K

6.54 ± 0.14

6.98 ± 0.14

5.35 ± 0.13

6.95 ± 0.97

4.60 ± 0.64

6.67 ± 0.66

3.96 ± 0.39

6.41 ± 0.41

3.40 ± 0.58

6.15 ± 0.33

3.36 ± 0.63

6.11 ± 0.12

A1 + B + E

6.83 ± 0.38

6.98 ± 0.89

5.29 ± 0.53

6.95 ± 0.96

4.55 ± 0.99

6.67 ± 0.11

3.91 ± 0.76

6.41 ± 0.41

3.36 ± 0.33

6.15 ± 0.51

3.34 ± 0.43

6.11 ± 0.11

A1 + B + K

6.76 ± 0.23

6.98 ± 0.27

5.41 ± 0.14

6.95 ± 0.23

4.65 ± 0.43

6.67 ± 0.14

4.00 ± 0.21

6.41 ± 0.27

3.44 ± 0.23

6.15 ± 0.21

3.42 ± 0.34

6.11 ± 0.27

A1 + B + E + K

6.69 ± 0.21

6.98 ± 0.29

5.38 ± 0.73

6.95 ± 0.21

4.63 ± 0.09

6.67 ± 0.42

3.98 ± 0.17

6.41 ± 0.42

3.42 ± 0.21

6.15 ± 0.48

3.40 ± 0.42

6.11 ± 0.21

A2

6.77 ± 0.37

6.98 ± 0.34

5.57 ± 0.21

6.95 ± 0.37

4.79 ± 0.53

6.67 ± 0.21

4.12 ± 0.37

6.41 ± 0.18

3.54 ± 0.21

6.15 ± 0.37

3.50 ± 0.44

6.11 ± 0.37

P

6.81 ± 0.42

6.98 ± 0.22

5.61 ± 0.38

6.95 ± 0.51

4.82 ± 0.42

6.67 ± 0.22

4.15 ± 0.32

6.41 ± 0.13

3.57 ± 0.42

6.15 ± 0.32

3.51 ± 0.22

6.11 ± 0.42

A2 + P

6.75 ± 6.98

6.98 ± 0.19

5.42 ± 0.25

6.95 ± 0.11

4.66 ± 0.25

6.67 ± 0.56

4.01 ± 0.39

6.41 ± 0.25

3.45 ± 0.34

6.15 ± 0.11

3.44 ± 0.56

6.11 ± 0.25