|
| Parameters | Effect | Observation | Conclusion |
| 1 | ATP synthesis from OXPHOS [9] [10] [11] | No ATP synthesis | Low ADP due to compartmentalization in dense granule | Energy released as heat |
| 2 | ROS formation [1] [12] [13] [14] | Platelet death by apoptosis | ROS formation due to incomplete OXPHOS | Lower life span of platelet |
| 3 | Solid organs and tissues | Not too hot | Normal temperature | Cannot serve as heat generators |
| 4 | RBC and WBC | No TCA cycle, ETC, and OXPHOS in RBC | No mitochondria in RBC and WBC are low in number | Cannot serve as heat generators |
| 5 | Stored ATP | Not available for heat generation | Used for vital functions | May not serve as heat generators |
| 6 | Exercise [15] [16] [17] [18] | More epinephrine production | More platelets near muscles | Temperature increased near muscle |
| 7 | Sex [19] [20] [21] [22] | Platelets number difference | Females have more platelets than males | Females’ body temperature is more than males’ |
| 8 | Pathological conditions [23] [24] [25] [26] | Platelets abnormal levels | Thrombocytopenia or thrombocythemia | Alternate mechanism |