| Group | Number of patients | Treatment program: 10 sessions—2 - 3 times a week. | |
| Ozone concentration (μg/ml) | Mix volume (ml) | ||
| 1 | 39 | 20 (no changes) | 250 (no changes) |
| 2 | 30 | One concentration per session: 20, 25, 25, 32, 32, 32, 40, 40, 50, 50 | 250 (no changes) |
| 3 | 30 | One concentration per session: 20, 20, 20, 25, 32, 32, 40, 40, 50, 50 | One volume per session: 250, 250, 250, 250, 360, 360, 360, 360, 480, 600 |
| 4 | 42 | 20 (no changes) | One volume per session: 250, 360, 360, 360, 420, 420, 480, 480, 600, 600 |