Risk of bias and applicability | 19 | Present evaluation of risk of bias and concerns regarding applicability for each study. | 5-7, Figure 1, Figure 2 |
Results of individual studies | 20 | For each analysis in each study (e.g. unique combination of index test, reference standard, and positivity threshold) report 2 × 2 data (TP, FP, FN, TN) with estimates of diagnostic accuracy and confidence intervals, ideally with a forest or receiver operator characteristic (ROC) plot. | 10-12, Figures 4-6, Table S1 |
Synthesis of results | 21 | Describe test accuracy, including variability; if meta-analysis was done, include results and confidence intervals. | 9-12, Table 3, |
Additional analysis | 23 | Give results of additional analyses, if done (e.g., sensitivity or subgroup analyses, meta-regression; analysis of index test: failure rates, proportion of inconclusive results, adverse events). | 11-13, Figure 7 |
DISCUSSION |
|
|
|
Summary of evidence | 24 | Summarize the main findings including the strength of evidence. | 13-14 |
Limitations | 25 | Discuss limitations from included studies (e.g. risk of bias and concerns regarding applicability) and from the review process (e.g. incomplete retrieval of identified research). | 15-16 |
Conclusions | 26 | Provide a general interpretation of the results in the context of other evidence. Discuss implications for future research and clinical practice (e.g. the intended use and clinical role of the index test). | 15 |
FUNDING |
|
|
|
Funding | 27 | For the systematic review, describe the sources of funding and other support and the role of the funders. | 16 |